Does dehydroepiandrosterone have any benefit in fertility treatment?

Current Opinion in Obstetrics & Gynecology
Bulent Urman, Kayhan Yakin

Abstract

Androgens and particularly dehydroepiandrosterone (DHEA) have been advocated as adjuncts to ovarian stimulation in women with diminished ovarian reserve. Given the limited number of options in these women it is understandable that both physicians and patients resort to treatments that are not evidence based. DHEA is such an adjunct and has been recently used extensively in women responding poorly to gonadotropins and women of advanced age seeking treatment with assisted reproductive techniques. Although androgens may be biologically plausible, current evidence is not sufficient to prove their effectiveness. Until well designed studies show a beneficial effect of DHEA supplementation in women with a diminished ovarian reserve, its widespread use should be discouraged. The patients should be counseled regarding the experimental nature of such a treatment.

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Citations

Jun 6, 2013·Journal of Assisted Reproduction and Genetics·Mazen R Fouany, Fady I Sharara
May 18, 2013·Reproductive Biology and Endocrinology : RB&E·Amarin NarkwicheanKannamannadiar Jayaprakasan
Apr 22, 2014·Reproductive Biomedicine Online·Jing GuoDongzi Yang
Feb 2, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Itai GatEdward A J Ryan
Jun 12, 2012·Reproductive Biomedicine Online·Norbert Gleicher, David H Barad
Oct 1, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jie LiLiuming Li
May 6, 2015·Nature Reviews. Endocrinology·Aya Shohat-TalNorbert Gleicher

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