Does Dietary-Induced Obesity in Old Age Impair the Contractile Performance of Isolated Mouse Soleus, Extensor Digitorum Longus and Diaphragm Skeletal Muscles?

Nutrients
Cameron HillJason Tallis

Abstract

Ageing and obesity independently have been shown to significantly impair isolated muscle contractile properties, though their synergistic effects are poorly understood. We uniquely examined the effects of 9 weeks of a high-fat diet (HFD) on isometric force, work loop power output (PO) across a range of contractile velocities, and fatigability of 79-week-old soleus, extensor digitorum longus (EDL) and diaphragm compared with age-matched lean controls. The dietary intervention resulted in a significant increase in body mass and gonadal fat pad mass compared to the control group. Despite increased muscle mass for HFD soleus and EDL, absolute isometric force, isometric stress (force/CSA), PO normalised to muscle mass and fatigability was unchanged, although absolute PO was significantly greater. Obesity did not cause an alteration in the contractile velocity that elicited maximal PO. In the obese group, normalised diaphragm PO was significantly reduced, with a tendency for reduced isometric stress and fatigability was unchanged. HFD soleus isolated from larger animals produced lower maximal PO which may relate to impaired balance in older, larger adults. The increase in absolute PO is smaller than the magnitude of weight gain, mean...Continue Reading

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Citations

Jan 29, 2020·The Journal of Experimental Biology·Guy A M MessaHans Degens
Jul 23, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cameron HillJason Tallis
Apr 30, 2019·Aging·Cameron Hill, Jason Tallis
Sep 11, 2020·Journal of Applied Physiology·Gisele C RodriguesPedro L Silva
Dec 19, 2020·Frontiers in Nutrition·Paul T MorganLeigh Breen
Jun 9, 2021·GeroScience·Ana P ValenciaDavid J Marcinek
Jun 18, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ian C SmithWalter Herzog

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