PMID: 2488086Jan 1, 1989Paper

Does digitalis work in chronic heart failure? The end of a 200-year-old controversy

Cardiovascular Drugs and Therapy
M Packer

Abstract

Controlled trials using modern methods of assessment in well-defined groups of patients have now convincingly demonstrated that digitalis is an effective and well-tolerated drug in patients with chronic heart failure who have left ventricular systolic dysfunction. These encouraging findings concerning digitalis, however, should not be construed to suggest that the drug should be used alone in the treatment of heart failure. Digitalis cannot adequately control the fluid retention seen in most patients with chronic heart failure; diuretics should be added to maintain sodium balance. Digitalis has not been shown to prolong life in chronic heart failure; converting-enzyme inhibitors should be added to reduce morbidity and mortality. All three drugs should be used together in the management of patients with this disorder.

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Citations

Sep 4, 2010·Health Policy·Sungwon ChangPatricia M Davidson
Oct 19, 2005·Journal of Cardiac Failure·James D NeatonMarvin A Konstam
Aug 28, 2010·Journal of the American College of Cardiology·Rutger J Van BommelJeroen J Bax
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Edoardo GrondaSusan Chambers

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