PMID: 9416784Jan 1, 1997Paper

Does dizocilpine (MK-801) inhibit the development of morphine-induced behavioural sensitization in rats?

Life Sciences
L J VanderschurenT J De Vries

Abstract

Intermittent morphine pretreatment (10 mg/kg/day for 14 days) induced long-lasting (one month post-treatment) sensitization to the locomotor effects of morphine and amphetamine in rats. Co-administration of the non-competitive NMDA-receptor antagonist dizocilpine (MK-801) (0.1 mg/kg) with morphine did not prevent the development of long-term behavioural sensitization. However, this dose of MK-801 did cause long-term sensitization to its own locomotor effects. Co-administration of 0.25 mg/kg MK-801 with morphine caused death in 60% of the animals. In the animals that survived MK-801 plus morphine pretreatment, neither short-term (3 days) nor long-term morphine-induced sensitization was observed. MK-801 alone (0.25 mg/kg/day for 14 days) induced short-term cross-sensitization to morphine. Thus, the development of long-term morphine-induced locomotor sensitization could only be prevented by a dose of MK-801 that yields a lethal combination with morphine. In addition, MK-801 induced sensitization to its own locomotor effects and cross-sensitization to morphine. These findings seriously question whether MK-801 can be used to study the development of morphine-induced behavioural sensitization.

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Citations

Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Vincent L H HoffmannTheo F Meert
Aug 23, 2002·Behavioural Brain Research·Capriles Nancy del RosarioLiliana Marina Cancela
Jul 15, 2009·Brain Research·María A AguilarJosé Miñarro
Dec 22, 2010·European Journal of Pharmacology·Carmen ManzanedoMarta Rodríguez-Arias
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alejandra M PacchioniLiliana M Cancela
Apr 25, 2003·Alcoholism, Clinical and Experimental Research·Christina N Lessov, Tamara J Phillips

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