PMID: 8582395Sep 1, 1995Paper

Does dobutamine prevent the rise in left ventricular filling pressures observed during exercise after heart transplantation?

European Heart Journal
P J VantrimpontW J Paulus

Abstract

The purpose of the study was to evaluate whether infusion of a beta-adrenergic agonist, prior to and during exercise, could compensate for reduced sympathetic stimulation and correct deficient acceleration of left ventricular relaxation, so preventing a rise in left ventricular filling pressures during exercise after cardiac transplantation. Abnormal left ventricular relaxation kinetics can contribute to exercise-induced diastolic dysfunction of the cardiac allograft. This was demonstrated in transplant recipients whose acceleration of left ventricular relaxation during exercise was almost negligible recently and whose elevation of left ventricular end-diastolic pressure was high. Decreased adrenergic tone due to denervation could be involved in deficient left ventricular lusitropic response to exercise, because acceleration of left ventricular relaxation during exercise depends on adequate sympathetic stimulation. Serial supine bicycle exercise was performed at an identical workload in eight transplant recipients while in the control state and during continuous infusion of dobutamine, titrated before exercise to achieve a heart rate matching the heart rate at peak exercise in the control state. During control exercise, heart r...Continue Reading

Citations

Apr 1, 2009·The Journal of Physiology·Ben T EschMark J Haykowsky
Jun 26, 2004·Circulation Research·David A KassWalter J Paulus

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