Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial

Fertility and Sterility
J D HirataB Ettinger

Abstract

To evaluate possible estrogenic effects of dong quai on vaginal cells and on endometrial thickness in postmenopausal women. Double-blind, randomized, placebo-controlled clinical trial. Department of Obstetrics and Gynecology in a large health maintenance organization (HMO). Seventy-one postmenopausal women (mean age [+/- SD], 52.4 +/- 6 years) who had follicle-stimulating hormone levels (third-generation assay) of > 30 mIU/mL with hot flashes. Subjects were randomized to treatment with either dong quai or placebo for 24 weeks. Endometrial thickness was measured by transvaginal ultrasonography; vaginal cells were evaluated for cellular maturation; menopausal symptoms were evaluated by reviewing the Kupperman index and the diary of vasomotor flushes. We observed no statistically significant differences between groups in endometrial thickness, in vaginal maturation index, in number of vasomotor flushes, or in the Kupperman index. Used alone, dong quai does not produce estrogen-like responses in endometrial thickness or in vaginal maturation and was no more helpful than placebo in relieving menopausal symptoms.

References

Oct 1, 1988·British Journal of Obstetrics and Gynaecology·T SporrongL A Mattsson
Mar 10, 1973·British Medical Journal·W H Utian
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·F L GeolaH L Judd
Aug 11, 1994·The New England Journal of Medicine·C L LoprinziN E Klatt
Jan 28, 1993·The New England Journal of Medicine·D M EisenbergT L Delbanco

❮ Previous
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Citations

Jun 27, 2007·Archives of Gynecology and Obstetrics·Deepti CheemaTarek El-Toukhy
Dec 6, 2011·Chinese Journal of Integrative Medicine·Chong ShouZitao Liu
Sep 28, 2005·Maturitas·Katherine M NewtonAndrea Z Lacroix
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·R S Rosenberg ZandE P Diamandis
Nov 26, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H J KangM M Hammoud
Jun 12, 2003·Obstetrics and Gynecology·Adriane Fugh-Berman
Jun 25, 1999·Journal of Nurse-midwifery·P A MurphyC Wade
Jan 7, 2004·Maturitas·Alyson L Huntley, Edzard Ernst
Mar 30, 2002·Journal of the American College of Cardiology·Georgianne Valli, Elsa Grace V Giardina
May 24, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Gregory Zapantis, Nanette Santoro
Apr 29, 2006·Journal of Natural Products·Shixin DengGuido F Pauli
Mar 5, 2002·Seminars in Dialysis·Beatrix Roemheld-Hamm, Naomi V Dahl
May 15, 2012·Health Care for Women International·Eun-Ok ImWonshik Chee
Oct 16, 2001·Clinical Obstetrics and Gynecology·M Taylor
Jul 13, 2000·Obstetrical & Gynecological Survey·V L BakerR B Jaffe
Oct 9, 2001·Obstetrical & Gynecological Survey·A A Ewies
Apr 9, 2005·Southern Medical Journal·Julie McKee, Sara L Warber
Jul 23, 1999·Pharmacotherapy·R L Page, J D Lawrence
Apr 20, 2001·Pharmacotherapy·L A Willhite, M B O'Connell
Mar 18, 2006·Treatments in Endocrinology·Paola Albertazzi
Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lian-Wei XuLan Kluwe
Jul 10, 2009·Women's Health·JoAnn V PinkertonRebecca S Kightlinger
Sep 27, 2005·Journal of Women's Health·Stacie E Geller, Laura Studee
Jan 14, 2010·Climacteric : the Journal of the International Menopause Society·M KontosI S Fentiman
Nov 2, 2012·Climacteric : the Journal of the International Menopause Society·K KoikeM Inoue
Aug 28, 2012·Climacteric : the Journal of the International Menopause Society·K KoikeM Inoue
Jun 29, 2010·Maturitas·Francesca Borrelli, Edzard Ernst
Jun 9, 2004·Mayo Clinic Proceedings·Lorraine A Fitzpatrick
Nov 21, 2002·Mayo Clinic Proceedings·Lorraine A Fitzpatrick, Richard J Santen
Nov 18, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Margaret Rees
Jul 18, 2008·Supportive Cancer Therapy·Yuan-Ching ChangWilliam C Dooley
Dec 18, 2012·Periodontology 2000·Beatrice J Edwards, Jin Li
Jun 9, 2004·Clinics in Geriatric Medicine·Syed H Tariq
Oct 24, 2002·Primary Care·Mohamad Sidani, James Campbell
Sep 30, 2009·The American Journal of Medicine·Clemens B TempferJohannes C Huber
Sep 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Ronit Haimov-Kochman, Drorith Hochner-Celnikier
Apr 17, 2015·In Silico Pharmacology·Chelsea N Powers, William N Setzer

❮ Previous
Next ❯

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