Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study

Critical Care Medicine
Yasser SakrDidier Payen

Abstract

The optimal adrenergic support in shock is controversial. We investigated whether dopamine administration influences the outcome from shock. Cohort, multiple-center, observational study. One hundred and ninety-eight European intensive care units. All adult patients admitted to a participating intensive care unit between May 1 and May 15, 2002. None. Patients were followed up until death, until hospital discharge, or for 60 days. Shock was defined as hemodynamic compromise necessitating the administration of vasopressor catecholamines. Of 3,147 patients, 1,058 (33.6%) had shock at any time; 462 (14.7%) had septic shock. The intensive care unit mortality rate for shock was 38.3% and 47.4% for septic shock. Of patients in shock, 375 (35.4%) received dopamine (dopamine group) and 683 (64.6%) never received dopamine. Age, gender, Simplified Acute Physiology Score II, and Sequential Organ Failure Assessment score were comparable between the two groups. The dopamine group had higher intensive care unit (42.9% vs. 35.7%, p=.02) and hospital (49.9% vs. 41.7%, p=.01) mortality rates. A Kaplan-Meier survival curve showed diminished 30 day-survival in the dopamine group (log rank=4.6, p=.032). In a multivariate analysis with intensive care...Continue Reading

References

Nov 1, 1994·Critical Care Medicine·G Van den BergheP Lauwers
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Sep 1, 1993·Critical Care Medicine·E RuokonenE J Hansen
Jan 1, 1997·British Journal of Anaesthesia·A R Bailey, K R Burchett
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·R BellomoM R Pinsky
Apr 20, 1999·JAMA : the Journal of the American Medical Association·P J PronovostE Bass
Aug 31, 2000·Critical Care Medicine·C MartinX Thirion
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·F J SaldíasJ I Sznajder
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Yochai AdirJacob Iasha Sznajder
Apr 20, 2004·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Management Guidelines Committee
Sep 3, 2004·Critical Care Medicine·Steven M HollenbergSergio Zanotti-Cavazzoni

❮ Previous
Next ❯

Citations

Mar 28, 2008·Intensive Care Medicine·Jean-Pierre QuenotUNKNOWN TECLA Study Group
Jul 16, 2010·Intensive Care Medicine·Alexandra ChronopoulosClaudio Ronco
Oct 18, 2013·Intensive Care Medicine·Patrick BistonDaniel De Backer
Feb 25, 2011·Inflammation·Koen J Hartemink, A B Johan Groeneveld
Aug 29, 2006·Current Infectious Disease Reports·Daniel De Backer
Mar 5, 2010·The New England Journal of Medicine·Jerrold H Levy
Mar 5, 2010·The New England Journal of Medicine·Daniel De BackerUNKNOWN SOAP II Investigators
Nov 1, 2013·The New England Journal of Medicine·Jean-Louis Vincent, Daniel De Backer
Apr 2, 2008·Critical Care Medicine·Gustavo A Ospina-TascónJean-Louis Vincent
Mar 28, 2009·Critical Care Medicine·David Bracco
Dec 31, 2008·Critical Care Medicine·Pedro R PóvoaUNKNOWN Portuguese Community-Acquired Sepsis Study Group
Aug 20, 2010·American Journal of Therapeutics·Mabrouk BahloulMounir Bouaziz
Aug 19, 2010·Clinical Nurse Specialist CNS·Patricia O'Malley
Dec 8, 2006·Seminars in Dialysis·Swaminathan Karthik, Alan Lisbon
Nov 3, 2007·BMJ : British Medical Journal·Iain Mackenzie, Andrew Lever
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Eric B MilbrandtDerek C Angus
Nov 26, 2010·American Journal of Respiratory and Critical Care Medicine·Steven M Hollenberg
Aug 21, 2013·Annals of Intensive Care·Pierre AsfarUNKNOWN French Opinion Group in Sepsis (FrOGS)
Sep 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Sarah E SiegelaarJ Hans DeVries
Jun 21, 2012·Critical Care : the Official Journal of the Critical Care Forum·Rick BezemerCan Ince
May 31, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jonathan Ball
Feb 13, 2007·Critical Care : the Official Journal of the Critical Care Forum·Nick AzarovMichael R Pinsky
May 2, 2007·Critical Care : the Official Journal of the Critical Care Forum·Matthias HeringlakeJulika Schön
Nov 16, 2007·Critical Care : the Official Journal of the Critical Care Forum·Gourang P Patel, Robert A Balk
Nov 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Anand KrishnanBala Venkatesh
May 20, 2008·Molecular Medicine·Matthieu LegrandCan Ince
Sep 17, 2008·Srpski arhiv za celokupno lekarstvo·Jasna JevdjićVladimir Vukićević
Jan 1, 2011·The Australasian Medical Journal·Bo Xu, Oziemski Peter
Aug 2, 2011·Saudi Journal of Anaesthesia·Avinash AgrawalPrakash Shastri
Nov 20, 2013·Journal of Pharmacology & Pharmacotherapeutics·Lisha Jenny JohnShoba Guido
Dec 2, 2014·Critical Care Clinics·Eliezer L BoseMichael R Pinsky
Jul 6, 2007·Der Internist·H Ebelt, K Werdan
Aug 7, 2013·Emergency Medicine Clinics of North America·Patrick J Maloney
Nov 17, 2012·The Surgical Clinics of North America·Jasmeet S Paul, Timothy J Ridolfi
Jan 16, 2007·Chest·Ramesh Venkataraman, John A Kellum
Nov 14, 2007·Chest·Steven M Hollenberg
May 15, 2012·Journal of Cardiothoracic and Vascular Anesthesia·André Y DenaultUNKNOWN BART Investigators
Nov 22, 2011·The American Journal of Emergency Medicine·Michael E WintersWilliam J Brady

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
E RiversEarly Goal-Directed Therapy Collaborative Group
The New England Journal of Medicine
James A RussellVASST Investigators
© 2021 Meta ULC. All rights reserved