Does dysplasia cause anatomical dysconnectivity in schizophrenia?

Schizophrenia Research
Edward BullmoreR M Murray

Abstract

Evidence is reviewed that dysplastic brain development in the second half of pregnancy predisposes to schizophrenia. We suggest that an important corollary of aberrant development at this stage of ontogenesis is abnormal afferentation of the cortical plate, and that this may be macroscopically measurable in terms of abnormal correlational structure in adult brain imaging data. This prediction is tested by analysis of multiple cortical volume measures on magnetic resonance imaging data acquired from 35 male right-handed schizophrenics and 35 matched controls. There are no significant differences between groups in global, intra-hemispheric or inter-hemispheric correlational structure; but schizophrenics are shown to have significantly reduced dependencies between frontal and temporal lobe volumes, and frontal and hippocampal volumes, in the left hemisphere. We conclude that anatomical dysconnectivity (between frontal and temporal cortex) in schizophrenia may be caused by dysplasia.

References

Apr 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P C ShamR M Murray
Aug 1, 1991·Psychological Medicine·D J Castle, R M Murray
Sep 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C D FrithP F Liddle
Aug 26, 1995·Lancet·D R Weinberger
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G TononiG M Edelman
Aug 1, 1993·Psychological Medicine·I HarveyR M Murray
Dec 24, 1997·Psychological Medicine·P W WoodruffR M Murray

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Citations

Sep 9, 2006·European Archives of Psychiatry and Clinical Neuroscience·Nicola AndreonePaolo Brambilla
Mar 25, 2011·European Archives of Psychiatry and Clinical Neuroscience·Guillermo HorgaMonte S Buchsbaum
Dec 21, 2000·Current Psychiatry Reports·G D Pearlson
Jun 14, 2005·Schizophrenia Research·Serge A MitelmanMonte S Buchsbaum
Jun 15, 2005·Schizophrenia Research·Paolo BrambillaMichele Tansella
Oct 30, 1998·Journal of Psychiatric Research·N DaviesR M Murray
Jan 11, 2000·Journal of Psychiatric Research·R M Murray, P Fearon
Mar 17, 2000·Brain Research. Brain Research Reviews·D CopolovC Pantelis
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron Alexander-BlochJay Giedd
Feb 2, 2013·Indian Journal of Psychiatry·Rohini ThimmaiahJohn P John
Feb 1, 2003·Acta Psychiatrica Scandinavica·M MarcelisJ van Os
Mar 31, 2015·Autism Research : Official Journal of the International Society for Autism Research·Hsiang-Yun ChienWen-Yih Isaac Tseng
Nov 22, 2011·NeuroImage·Heike TostAndreas Meyer-Lindenberg
Jul 15, 2015·Epilepsy & Behavior : E&B·Boris C BernhardtDonald W Gross
Jul 2, 2005·NeuroImage·Serge A MitelmanLina Shihabuddin
Oct 4, 2005·Schizophrenia Research·Matthew R BroomeRobin M Murray
Feb 18, 2014·Schizophrenia Research·Yuanchao ZhangChing-Po Lin
Sep 18, 2012·Schizophrenia Research·Yuanchao ZhangTianzi Jiang
Jul 19, 2013·Cerebral Cortex·Boris C BernhardtTania Singer
May 29, 2013·NeuroImage·Alan C Evans
Nov 26, 2009·NeuroImage·Stefano Marenco, Eugenia Radulescu
Sep 10, 2014·Frontiers in Human Neuroscience·Anne L Wheeler, Aristotle N Voineskos
Mar 10, 2004·International Review of Neurobiology·Daniel G Stewart, Kenneth L Davis
Oct 23, 2016·Journal of Psychiatric Research·Huawang WuJiaojian Wang

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