Does dyspnoea during dipyridamole cardiac stress testing indicate bronchospasm and is the pretest clinical history predictive of this side-effect?

European Journal of Nuclear Medicine
T LeithaS Falger-Banyai

Abstract

This study investigates the acute effects of intravenous dipyridamole (0.7mg/kg) on pulmonary airflow in relation to clinical parameters suggestive of chronic obstructive pulmonary disease (COPD) in order to assess predictive and causative factors of dyspnoea during cardiac stress testing. Mild pulmonary airflow obstruction was noted in all patients, but reached statistical significance only in small airways (FEF75-85%: -7%; P=0.034). The changes in pulmonary function parameters were independent of the clinical history. Dyspnoea under dipyridamole stress testing occurred in parallel with angina, yet was not associated with ischaemic or non-ischaemic left ventricular dysfunction. These data do not support the use of dipyridamole stress testing in asthmatics, but show that (1) the acute effects of a diagnostic dose of dipyridamole on pulmonary airflow are mild even in patients with a history suggestive of COPD and (2) dyspnoea during dipyridamole testing is not necessarily indicative of bronchospasm.

References

Oct 1, 1975·Thorax·J B MacdonaldA Seaton
Jul 1, 1990·Chest·J J Houben
Feb 1, 1988·American Heart Journal·A S IskandrianN Auerbach

❮ Previous
Next ❯

Citations

Jul 28, 2007·International Journal of Cardiology·William J van GaalK C Allman
Oct 31, 2015·Thoracic Surgery Clinics·Hari B Keshava, Daniel J Boffa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.