Does early exercise attenuate muscle atrophy or bone loss after spinal cord injury?

Spinal Cord
M G PanissetD El-Ansary

Abstract

To systematically identify and assess the evidence on the efficacy of exercise initiated early after traumatic spinal cord injury (SCI). A comprehensive search (Any-2014) of eleven databases identified studies evaluating exercise interventions initiated within 12 weeks after SCI on muscle and bone loss in paralyzed limbs and comparing with standard care or immobilization. Two reviewers assessed methodological quality. One reviewer extracted data and critiqued results according to the Spinal Cord Injury Rehabilitation Evidence body of evidence framework. A total of 2811 titles were screened. Eleven studies were included: five randomized controlled trials, four cohort studies and two within-subject control studies. All provided level II evidence with a moderate risk of bias. Two studies found significant positive effects of high-load FES-resisted stance on physiological measures of muscle. Three reported positive effects of 3 months of Functional Electrical Stimulation (FES) on muscle size. Two studies found positive effects of 6-month body-weight supported treadmill training or FES on trabecular bone using pQCT. We found consistent evidence of positive effects of early exercise on muscle, possibly related to load intensity of th...Continue Reading

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Citations

Jun 9, 2018·International Journal of Molecular Sciences·Dana M OtzelJoshua F Yarrow
Oct 9, 2019·Disability and Rehabilitation. Assistive Technology·Bastien MoineauSander L Hitzig
Mar 17, 2018·Experimental and Therapeutic Medicine·Bo-Lun ZhaoLi-Bin An
Nov 11, 2020·Archives of Physical Medicine and Rehabilitation·Pierre AsselinAnn M Spungen
Mar 24, 2020·Journal of Agricultural and Food Chemistry·Jingjie ZhangJing Wang

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