Does elevated parathyroid hormone concentration predict cognitive decline in older people?

Aging Clinical and Experimental Research
Mikko P BjörkmanReijo S Tilvis

Abstract

Increased parathyroid activity has been associated with impaired cognitive function, although the predictive value of parathyroid hormone (PTH) for cognitive decline has not yet been fully investigated. This association was evaluated in random persons of age cohorts of 75, 80 and 85 years in a 10- year longitudinal prospective study. Cognition of patients (n=514) was assessed with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) at baseline and at intervals of one, five and ten years. Clinical data were collected and serum PTH, ionized calcium (Ca2+) and creatinine as well as apolipoprotein E (APOE) alleles were determined at baseline. Impaired cognition (MMSE<24 or CDR> or =1) was associated with older age, impaired renal function, and elevated PTH (> or =62 ng/L, IV-quartile) at baseline. Elevated PTH indicated a 2-fold risk of an at least 4-point decrease in MMSE (OR 2.20) and a 3-fold risk of an increase in CDR-class (OR 3.20) within the first year of follow- up. The risk remained significantly elevated even after controlling for age, gender, baseline cognition, serum Ca2+, creatinine, and APOE4 (OR 2.24 for MMSE; OR 2.12 for CDR). High PTH also predicted cognitive decline within a five-year follo...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 1, 1972·American Journal of Clinical Pathology·E M Gindler, J D King
Sep 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M AkmalS G Massry
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Dec 20, 2003·Current Opinion in Oncology·Göran Akerström, Per Hellman
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Reijo S TilvisTimo E Strandberg
Feb 26, 2005·Clinical Endocrinology·Leif Mosekilde
Jul 14, 2006·Acta Psychiatrica Scandinavica·D I SitzerD V Jeste
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Consuelo H WilkinsJohn C Morris
Jul 3, 2007·The Oncologist·James W Suliburk, Nancy D Perrier
Sep 14, 2007·Journal of Alzheimer's Disease : JAD·Elena MarianiPatrizia Mecocci
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Mar 12, 2008·American Journal of Alzheimer's Disease and Other Dementias·Sahoo Saddichha, Vibha Pandey
Apr 23, 2008·European Journal of Endocrinology·Mikko P BjörkmanReijo S Tilvis
May 27, 2008·Dementia and Geriatric Cognitive Disorders·C OudshoornT J M van der Cammen
Jun 4, 2008·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Jamie S Myers

❮ Previous
Next ❯

Citations

May 26, 2012·TheScientificWorldJournal·Yan ZhaoHong-Fang Ji
Oct 13, 2010·Journal of Neuroengineering and Rehabilitation·Cedric AnnweilerOlivier Beauchet
Jun 2, 2017·World Journal of Orthopedics·Candice L DowneyEleftherios Tsiridis
Jul 6, 2010·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Elizabeth Pogge
May 27, 2015·PloS One·Ilianna LouridaDavid J Llewellyn
Dec 29, 2011·American Journal of Alzheimer's Disease and Other Dementias·Khanh Vinh Quôc Lu'o'ng, Lan Thi Hoàng Nguyên
Mar 29, 2014·The Journal of Nutrition, Health & Aging·B BartaliJ H Kang
Feb 4, 2011·Journal of the American Geriatrics Society·E Paul CherniackSilvina Levis
Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Feb 6, 2014·Expert Opinion on Drug Discovery·Azadeh ManayiMohammad Abdollahi
Jun 1, 2016·Geriatrics & Gerontology International·Zhiyuan ShenZhongquan Sun
May 15, 2020·The American Journal of Pathology·Vidyani SuryadevaraMonte S Willis

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.