Does endothelium agree with the concept of idiopathic hepatic vessel thrombosis?

World Journal of Gastroenterology : WJG
Ozgur HarmanciYusuf Bayraktar

Abstract

To investigate the major steps of thrombogenesis and to identify the differences in these steps between idiopathic patient group and control group. Fibrinogenesis was studied by measuring the activated factor VII, total and free levels of tissue factor pathway inhibitor (TFPI). The fibrinolysis step was investigated by determining the global fibrinolytic capacity. The endothelial function was assessed by measuring the levels of soluble adhesion molecules, namely soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1) and soluble E-selectin molecule. The exclusion criteria from "idiopathic" patient group were abdominal surgery, pregnancy, use of oral contraceptives, anti-phospholipid syndrome, Behçet's disease, cancer, myeloproliferative diseases. The congenital factors like mutations of factor-V Leiden and prothrombin, deficiencies of proteins C and S, antithrombin, hyperhomocysteinemia and hyperfibrinogenemia were ruled out. The total number of patients was reduced from 96 to 9 (7 with portal vein thrombosis, 2 Budd Chiari syndrome) by exclusion criteria. The levels of adhesion molecules sICAM-1, sVCAM-1, free TFPI levels and global fibrinolytic capacity were significantly diffe...Continue Reading

References

Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H DenningerD Valla
Mar 23, 2001·Pathology, Research and Practice·Y NakanumaK Katayanagi
Oct 27, 2001·Circulation Research·G J Blake, P M Ridker
Apr 3, 2002·Seminars in Liver Disease·Shiv K Sarin, Shri Ram Agarwal
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Kunio Okuda

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Citations

Mar 18, 2008·Digestive Diseases and Sciences·Yusuf BayraktarFerhun Balkanci

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