Does endothelium-derived hyperpolarizing factor play a role in endothelium-dependent component of electrical field stimulation-induced vasorelaxation of rat mesenteric arterial rings?

Journal of Cardiovascular Pharmacology
Melike Hacer Ozkan, S Uma

Abstract

Electrical field stimulation (EFS)-induced, nonadrenergic, noncholinergic vasodilation was investigated in rat mesenteric arterial rings. Tetrodotoxin (10(-6) M), capsaicin (10(-5) M), or L-NAME (10(-4) M) failed to change the EFS-induced relaxations, whereas they were increased with indomethacin (10(-5) M). Removal of the endothelium caused approximately 20% reduction in the maximum response, whereas precontraction with 40 mM KCI abolished the relaxations at all frequencies. Iberiotoxin (3 x 10(-7) M) attenuated the relaxations in endothelium-intact tissues but blocked completely those in endothelium-denuded arteries. Combination of TRAM-34 (10(-5) M) with apamin (5 x 10(-7) M) and single administrations of NiCI2 (5 x 10(-4) M), ruthenium red (3 x 10(-5) M), and 18[alpha]-glycyrrhetinic acid (10(-4) M) significantly reduced the responses only in endothelium-intact tissues. These data indicate that in rat mesenteric arteries, EFS leads to vasodilation through both endothelium-dependent and endothelium-independent mechanisms. The major component of the relaxation is endothelium independent and seems to occur via BK(Ca) channels, whereas endothelium-dependent component is likely to be mediated by endothelium-derived hyperpolarizi...Continue Reading

References

Oct 1, 1993·British Journal of Pharmacology·G BkailyM Rola-Pleszczynski
Jan 1, 1996·Free Radical Biology & Medicine·Z S Katusic
Jul 1, 1997·Acta Physiologica Scandinavica·G G GearyR R Gonzalez
Aug 10, 1999·Japanese Journal of Pharmacology·R SaitoH Kamiya
Mar 22, 2000·British Journal of Pharmacology·J F QuignardP M Vanhoutte
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P JolmaI Pörsti
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G G Emerson, S S Segal
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H TomiokaM Kanno
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K A DoraX Yao
Aug 4, 2001·Nitric Oxide : Biology and Chemistry·B GümüşelS Uma
Jun 25, 2002·Trends in Neurosciences·Colin D McCaigMin Zhao
Aug 29, 2002·Journal of Cardiovascular Pharmacology·Jean-François QuignardPaul M Vanhoutte
May 22, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xavier F FigueroaBrian R Duling

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Citations

Jan 15, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Melike Hacer OzkanSerdar Uma
Mar 29, 2014·Pharmacological Reviews·Marie BillaudBrant E Isakson
Sep 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rui ZhangRoshanak Rahimian

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