Does endotoxin stimulate cells by mimicking ceramide?

Immunology Today
S D Wright, R N Kolesnick

Abstract

Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.

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