Does enteral glutamine supplementation decrease infectious morbidity?

Surgical Infections
Alison Saalwachter SchulmanR G Sawyer

Abstract

Although some studies have demonstrated lower infectious morbidity in patients receiving supplemental glutamine, there remains no consensus on the utility of such treatment. This study was designed to investigate the effects of supplemental enteral glutamine on the rate and outcomes of infection in critically ill surgical patients. All 185 surgical and trauma patients admitted to a single university surgical trauma intensive care unit (STICU) over an approximately three-year period who were to receive enteral nutrition support were assigned sequentially to one of three diets: standard 1-kCal/mL feedings with added protein (Group 1), standard feedings with glutamine 0.6 g/kg per day (Group 2), or immune-modulated feedings with a similar amount of glutamine (Group 3). Group compositions and patient characteristics were similar at baseline. Data were collected prospectively on infections acquired during hospitalization. A total of 119 patients had at least one infection: 59% of the patients in Group 1, 64% of Group 2, and 69% of Group 3 (p = NS). There were no differences among the groups in the mean number of infections. The most common sites in all groups were the lungs, blood, and urine; and the frequencies of these infections ...Continue Reading

References

Sep 1, 1990·Lancet·M Parry-BillingsE A Newsholme
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jun 29, 2000·Journal of the American College of Surgeons·S J PelletierR G Sawyer
Feb 24, 2001·World Journal of Surgery·B I Labow, W W Souba
Mar 31, 2001·Intensive Care Medicine·H M Oudemans-van StraatenD F Zandstra
Sep 5, 2001·The Journal of Nutrition·A M KarinchW W Souba
Mar 16, 2002·The British Journal of Nutrition·Francis J Andrews, Richard D Griffiths
Sep 11, 2002·The Journal of Nutrition·Petra G BoelensPaul A M Van Leeuwen
Sep 28, 2002·Critical Care Medicine·Frantisek NovakXiangyao Su
Aug 19, 2003·Intensive Care Medicine·John C HallRosalie McCauley
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Paul E Wischmeyer

❮ Previous
Next ❯

Citations

Sep 22, 2007·Critical Care Medicine·Thomas BongersAnne McArdle
Jun 22, 2010·Anais Da Academia Brasileira De Ciências·Gisele P OliveiraPatricia R M Rocco
Jul 10, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Petra Pavlickova AimovaZdenek Zadak
Dec 31, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Peter J D Andrews
Feb 1, 2013·Anaesthesia and Intensive Care·R M Al BalushiJ D Paratz
Dec 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiuwen WuJianan Ren
Sep 23, 2008·The Journal of Nutrition·Erich Roth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.