Does exposure to di(2-ethylhexyl) phthalate in pre-pubertal boars affect semen quality post-puberty?

International Journal of Andrology
Linda SpjuthH Rodriguez-Martinez

Abstract

Di(2-ethylhexyl) phthalate (DEHP), a plastic softener used in polyvinyl chloride (PVC) products, has been ascribed to have toxic effects on animal reproduction. The present study aimed at determining potential late effects of pre-pubertal oral exposure to DEHP on semen quality in young pigs. Ten pairs of cross-bred male siblings were used. One brother in each pair became, at random, the test animal while the other acted as control. Test males were exposed to 300 mg/kg body weight (bw) of DEHP administered orally three times a week from 3 to 7 weeks of age. The control group was given placebo (water). Semen analyses started when the boars reached 6 months of age, with semen collected twice weekly, until animals were 9 months of age. Semen was evaluated for ejaculate volume, sperm concentration, total sperm count, sperm motility, sperm morphology (including presence of cells other than spermatozoa) and sperm plasma membrane integrity. Total sperm motility tended to be lower while local motility was higher in the DEHP-exposed group compared with controls (p = 0.07) when assessed by computer-assisted sperm analysis. The DEHP-exposed group had a significantly (p < 0.05) lower percentage of spermatozoa with tailless, defective heads ...Continue Reading

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Citations

Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·U Magnusson
Jun 7, 2014·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Sep 3, 2013·Reproductive Toxicology·Ulf Magnusson, Karl Ljungvall
Oct 8, 2016·Environmental Science and Pollution Research International·Maryam ZareanRoya Kelishadi

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