Does feeding induce maximal stimulation of protein balance?

Current Opinion in Clinical Nutrition and Metabolic Care
Felix LiebauOlav Rooyackers

Abstract

Muscle wasting is dramatic in critically ill patients and related to worsened outcome. The question is whether this can be prevented or reduced by adequate protein feeding. Recommendations for protein requirements are different between different societies, because of limited and weak evidence. Most studies, on which these recommendations are based, use nitrogen balance as primary outcome. However, nitrogen balance to estimate protein needs over short periods, is not reliable. Studies using tracer methodology to assess the effects of feeding on whole-body protein synthesis, breakdown and balance, show that both adult and pediatric critically ill patients can utilize parenterally and enterally given proteins or amino acids to build body protein, and that the extra amino acids are not oxidized. Recent studies show a positive correlation between protein intake and protein balance, with many patients reaching a positive protein balance. However, many questions remain. Especially whether adult patients should have a constant positive protein balance, whether the route of administration affects utilization, which proteins are synthesized and whether these are beneficial, is more protein better and what is the upper limit, and whether ...Continue Reading

References

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Mar 4, 2015·The American Journal of Clinical Nutrition·Felix LiebauOlav Rooyackers
Apr 18, 2015·Critical Care : the Official Journal of the Critical Care Forum·Felix LiebauOlav Rooyackers

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Citations

Dec 23, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Daren K HeylandRenee D Stapleton
Nov 20, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Alexandra MitchellStephen Taylor
Dec 24, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kavita SharmaMalcolm K Robinson
Dec 27, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Michael TielandYves Boirie
Jun 27, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Filippo G Di GirolamoGianni Biolo
Dec 13, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Jayshil J PatelDaren K Heyland
Dec 8, 2017·Critical Care : the Official Journal of the Critical Care Forum·Martin Sundström RehalJan Wernerman
Jun 14, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Mariëlle P K J EngelenNicolaas E P Deutz
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Robert G MartindaleStephen A McClave
Dec 17, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Felix LiebauOlav Rooyackers

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