PMID: 8592653Nov 1, 1995Paper

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

Pharmaceutical Research
H Lennernäs

Abstract

Hydrophilic and charged solutes have a lower membrane permeability which is due to a lower partition into the lipid membrane (low solubility in the membrane phase) and/or a slower transcellular diffusion coefficient. They are therefore anticipated to be absorbed through the paracellular route, which is a consequence of diffusion and a convective volume flow through the water-filled intercellular space. Two approaches have been used to investigate the mechanisms underlying the paracellular drug transport across the intestinal mucosa: (a) including water transport by exposing the apical side of the epithelium with a hypotonic solution, and (b) stimulated paracellular transport by widening of tight junction and increased water absorption as a consequence of the sodium-coupled transport of nutrients. Among the first studies that recognized this fluid flux dependent transmucosal transport of drugs, was one published by Oschenfahrt & Winne in 1973 and the one by Kitazawa et al. in 1975. During the last two decades the importance of this paracellular route for drug delivery have been explored in vitro and in situ. The limits concerning molecular weight, shape, ionization and the effect of physiological stimulants, such as luminal conc...Continue Reading

Citations

Nov 1, 1996·Clinical Pharmacology and Therapeutics·A LindahlH Lennernäs
Apr 30, 1998·The Annals of Pharmacotherapy·B E GidalD E Cook
Jun 30, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Josias H HammanAwie F Kotzé
Aug 19, 2007·Pharmaceutical Research·Lana X GarmireC Anthony Hunt
Sep 16, 2010·Journal of Veterinary Pharmacology and Therapeutics·M N Martinez, R P Hunter
Mar 1, 2013·EJNMMI Research·Timothy E CorcoranJoseph M Pilewski
Mar 3, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ayman F El-Kattan, Manthena V S Varma
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·V Hayden ThomasAyman El-Kattan
Nov 6, 2010·Pharmaceutical Research·Xiangli LiuAlfred Fahr
Feb 20, 2009·Biopharmaceutics & Drug Disposition·Venugopal P MarasanapalleBhaskara R Jasti
Jun 5, 2002·Journal of Clinical Pharmacology·Marilyn N Martinez, Gordon L Amidon
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Lennernäs
Jul 1, 1996·Journal of Peptide Science : an Official Publication of the European Peptide Society·G Fricker, J Drewe
Jan 1, 1996·Journal of Drug Targeting·W Wang
Aug 18, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·R SiekmeierW Jaross
Aug 23, 2002·Clinical Pharmacokinetics·Patric StenbergPer Artursson
Mar 7, 2009·Chemical Reviews·Stefan Balaz
Jul 27, 2014·The Journal of Experimental Biology·Edwin R PriceWilliam H Karasov
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J KarlssonP Artursson
Feb 21, 2003·International Journal of Pharmaceutics·Karl A LevisOwen I Corrigan
Apr 21, 1998·Journal of Pharmaceutical Sciences·H Lennernäs
May 20, 1998·Journal of Pharmaceutical Sciences·R E OliverM Rowland
May 25, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kyoung-Jin LeeYong-Hee Lee
Aug 23, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alfred FahrMathew L S Leigh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.