PMID: 8973704Dec 1, 1996Paper

Does free to total ratio of prostate-specific antigen alter decision-making on prostatic biopsy?

Urology
G AlivizatosA M Dimopoulos

Abstract

For patients with prostate specific antigen (PSA) values of 4-10 ng/mL, some urologists perform prostatic biopsies depending upon the findings of digital rectal examination (DRE) and transrectal ultrasonography (TRUS), and others perform biopsies on most of these men regardless of the findings of DRE and TRUS. The purpose of this study was to examine whether the information given by the measurement of the ratio of free to total (F/T) PSA can alter decision-making on prostatic biopsy. One hundred and two (102) men with PSA values between 4 and 10 ng/mL, were included in this study. All men were examined with DRE and TRUS; a F/T PSA ratio was also measured, and six prostatic biopsies were taken from each patient. In 102 men who were biopsied, 22 (21.5%) prostatic carcinomas were identified. Among these 22 cancer patients, 13 had abnormal findings in DRE and/or TRUS and would have been biopsied and diagnosed anyway. If we use only the F/T PSA ratio (cut-off value 0.20) to decide whom to biopsy, we would have diagnosed 16/22 cancers; the difference between these two procedures was not statistically significant (P = 0.17). If we decide to biopsy those patients who have abnormal findings in DRE and/or TRUS and those who have a F/T PS...Continue Reading

References

Apr 22, 1992·JAMA : the Journal of the American Medical Association·H B CarterP C Walsh
Jan 1, 1990·Urologia Internationalis·C D JurincicK F Klippel
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Citations

Jan 30, 2004·Journal of Cancer Research and Clinical Oncology·Carlo VicentiniMauro Bologna
Apr 6, 2000·International Journal of Urology : Official Journal of the Japanese Urological Association·M TanakaJ Shimazaki

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