Does growth hormone treatment influence pubertal development in short children?

Hormone Research in Pædiatrics
Anna-Karin Albinstudy group

Abstract

To study the influence of growth hormone (GH) treatment on the initiation and progression of puberty in short children. This prospective, randomized, controlled study included 124 short children (33 girls) who received GH treatment (Genotropin®; Pfizer Inc.) from a mean age of 11 years until near adult height [intent-to-treat (ITT) population]. Children were randomized into three groups: controls (n = 33), GH 33 μg/kg/day (n = 34) or GH 67 μg/kg/day (n = 57). Prepubertal children at study start constituted the per-protocol (PP) population (n = 101). Auxological measurements were made and puberty was staged every 3 months. Serum sex-steroid concentrations were assessed every 6 months. No significant differences were found between the groups, of both PP and ITT populations, in time elapsed from start of treatment until either onset of puberty, age at start of puberty or age at final pubertal maturation in either sex. In the ITT population, pubertal duration was significantly longer in GH-treated girls, and maximum mean testicular volume was significantly greater in GH-treated boys than controls, but there were no differences in testosterone levels between the groups. GH treatment did not influence age at onset of puberty and did ...Continue Reading

Citations

Jan 13, 2015·International Journal of Endocrinology·Kerry L Hull, Steve Harvey
Apr 15, 2014·Arquivos brasileiros de endocrinologia e metabologia·Daniela F CardosoManuel H Aguiar-Oliveira
Oct 24, 2018·Endocrine Connections·Jin Kyu OhJae-Seung Paick
Mar 12, 2016·The Journal of Clinical Endocrinology and Metabolism·Manouk van der SteenAnita C S Hokken-Koelega
Mar 27, 2019·The Journal of Clinical Endocrinology and Metabolism·Liora LazarYael Lebenthal
Apr 20, 2021·Frontiers in Endocrinology·Rossella CannarellaAldo E Calogero

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