Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis

Trends in Immunology
J P McFaddenI Kimber

Abstract

Contact allergy data indicates that atopics have heightened oral tolerance to haptens (chemical allergens). We speculate here, that artificially increased oral exposure to chemicals compete with dietary proteins for the development of oral tolerance, predisposing to the acquisition of food protein allergy and representing one driver for the increasing prevalence of protein allergy and/or atopy. Hapten exposure via other surfaces such as the skin and airways might also be important in promoting atopic disease. Consistent with this hypothesis it is notable that over 40 years, with the huge increase in atopic disease, there has also been an increase in dietary hapten exposure through processed food, formula milk and oral antibiotic and drug use.

References

Jan 1, 1990·Journal of Nutritional Science and Vitaminology·J Mauron
Dec 1, 1982·Journal of the Science of Food and Agriculture·A Hobson-Frohock
Oct 1, 1993·Contact Dermatitis·N SutthipisalE Cronin
Apr 1, 1993·Contact Dermatitis·E Cronin, J P McFadden
Jan 1, 1997·The European Respiratory Journal·P N Black, S Sharpe
May 16, 1998·Experimental Dermatology·M RöckenA Szentivanyi
Jun 5, 1998·The Australasian Journal of Dermatology·D M Rubel, S Freeman
Oct 1, 1996·Nature Biotechnology·J D AstwoodR L Fuchs
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B NiggemannU Wahn
Mar 18, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·S M SopoA Stabile
Sep 12, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·S M TariqS H Arshad
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·C E Baena-Cagnani, A Teijeiro
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Angelika Paschke, Matthias Besler
Feb 28, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M EdelbauerZ Szépfalusi
Apr 3, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Katsuo MatsumotoHachiro Tagami
Dec 4, 2004·Allergy·P N Black
Dec 14, 2004·International Archives of Allergy and Immunology·Randall A KopperA Wesley Burks
Feb 25, 2005·The British Journal of Dermatology·C FlohrH C Williams
Aug 13, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Radoslaw Spiewak
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kang-Mo AhnKyu-Earn Kim
Mar 15, 2006·Immunobiology·Eliana A FutataMaria Notomi Sato
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M PaunioO P Heinonen
Jun 24, 2006·Pharmacoepidemiology and Drug Safety·John P MulloolyJulie E Maher
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Hywel Williams, Carsten Flohr
Jul 27, 2006·Allergy·H-Y WooH-K Lee
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Eric B BrandtMarc E Rothenberg
Aug 22, 2006·Inflammation & Allergy Drug Targets·Ana M C Faria, Howard L Weiner
Oct 26, 2006·Nature Reviews. Immunology·Graham Devereux
Jan 16, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Femke van Wijk, Léon Knippels
Jun 5, 2007·Trends in Immunology·Robin E Callard, John I Harper
Jun 15, 2007·Journal of Epidemiology and Community Health·Olf HerbarthThomas Richter
Aug 19, 2007·International Immunology·Xianzhu WuErnst Gleichmann
Sep 25, 2007·The Journal of Pediatrics·David J HillJohn B Carlin
Apr 29, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maja AleksicAnne Dell

❮ Previous
Next ❯

Citations

Jul 21, 2012·The American Journal of the Medical Sciences·Zhi-Qiang LiuPing-Chang Yang
Aug 1, 2009·Trends in Immunology·Carlo Selmi, M Eric Gershwin
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Crameri
Jun 23, 2011·Contact Dermatitis·Jacob P ThyssenJeanne D Johansen
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J P McFaddenI Kimber
Jul 22, 2014·Journal of Applied Toxicology : JAT·Aristo VojdaniPartha Sarathi Mukherjee
Jun 30, 2009·Human Immunology·Yaron Ilan
Jul 21, 2015·Toxicological Research·Kwangmi Kim
May 20, 2015·World Journal of Gastroenterology : WJG·Eran IsraeliYaron Ilan
Aug 29, 2013·The British Journal of Dermatology·J P McFaddenI Kimber
Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus
Jul 26, 2017·Journal of Chromatography. a·Hong WangZongtao Lin
Jun 20, 2021·The Journal of Allergy and Clinical Immunology·Iben Frier RugeJacob P Thyssen
May 14, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Bruce R Gordon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved