Does HbA1c Level Have Clinical Implications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting? A Systematic Review and Meta-Analysis

International Journal of Endocrinology
Jia ZhengXinhua Xiao

Abstract

The aim of the present study was to investigate whether HbA1c was related to clinical outcomes in diabetic patients undergoing CABG surgery. A literature search was carried out satisfying the predefined inclusion criteria from Pubmed, Embase, and Cochrane Library. Differences were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) to assess the relationships of preoperative HbA1c levels and clinical prognosis in diabetic patients. 7895 diabetic patients undergoing CABG surgery from eight published studies were finally involved in this meta-analysis. Combined analyses revealed that the higher HbA1c level was significantly associated with increased risks of all-cause mortality (OR 1.56, 95%CI 1.29-1.88), myocardial infarction (OR 2.37, 95%CI 1.21-4.64), and stroke (OR 2.07, 95%CI 1.29-3.32) after CABG surgery. However, there was no significant relationship between HbA1c levels and renal failure (OR 2.08, 95%CI 0.96-4.54) in diabetic patients undergoing CABG surgery. Our meta-analysis demonstrated that the HbA1c level is potentially associated with increased risks of all-cause mortality, myocardial infarction, and stroke in diabetic subjects undergoing CABG surgery. However, further clinical studies with larger sam...Continue Reading

References

Jan 1, 1992·Epidemiologic Reviews·K Dickersin, J A Berlin
Jan 5, 2002·Diabetes Care·UNKNOWN American Diabetes Association
Jul 27, 2002·Journal of the American College of Cardiology·Jeffrey L CarsonStephen H Schneider
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·S HadjadjR Marechaud
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Mar 24, 2005·JAMA : the Journal of the American Medical Association·James D Flaherty, Charles J Davidson
Apr 14, 2005·JAMA : the Journal of the American Medical Association·Cynthia L Leibson, K M Venkat Narayan
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Sep 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·Chanaka RajakarunaRaimondo Ascione
Jul 9, 2008·Scandinavian Cardiovascular Journal : SCJ·Thomas AlseriusTorbjörn Ivert
Sep 23, 2008·The Journal of Thoracic and Cardiovascular Surgery·Michael E HalkosVinod H Thourani
Jul 16, 2010·The Journal of Clinical Endocrinology and Metabolism·Hiroaki SatoThomas Schricker
Nov 23, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Piotr KnapikMarian Zembala
Dec 7, 2010·Trends in Cardiovascular Medicine·Caroline S Fox
May 4, 2011·Statistics in Medicine·Hathaikan ChootrakoolRongxian Yue
Jan 4, 2012·Diabetes Care·UNKNOWN American Diabetes Association
Jul 19, 2012·Cardiovascular Diabetology·Seyed Ebrahim KassaianEbrahim Nematipour
May 15, 2013·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Zahra FaritousRasoul Azarfarin
Mar 13, 2014·European Journal of Preventive Cardiology·Jacek KowalczykZbigniew Kalarus

❮ Previous
Next ❯

Citations

May 1, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Haleh ChehregoshaFaramarz Ismail-Beigi
Jun 29, 2021·The Journal of Thoracic and Cardiovascular Surgery·Claudio CorazzariRoberto Lorusso
Aug 19, 2021·Pilot and Feasibility Studies·Richard I G HoltUNKNOWN OCTOPuS study group
Dec 10, 2021·Journal of Wound Care·Issa M HweidiAudai A Hayajneh
Apr 10, 2019·The Journal of Thoracic and Cardiovascular Surgery·Dustin Scott Kehler

❮ Previous
Next ❯

Methods Mentioned

BETA
Coronary Artery Bypass

Software Mentioned

RevMan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.