Does hepatitis C increase the accumulation of advanced glycation end products in haemodialysis patients?

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Stefan ArsovGerhard Rakhorst

Abstract

Hepatitis C may cause increased levels of oxidative stress that contribute to accumulation of advanced glycation end products (AGEs), which increase the risk of cardiovascular disease (CVD). The aim of this study was to determine the influence of hepatitis C on AGE accumulation in haemodialysis patients. AGE accumulation was measured by means of skin autofluorescence (AF) in 92 haemodialysis (HD) patients and 93 age-matched healthy controls. In the HD patients, CVD-related biochemical variables were also measured. The HD patients were tested for hepatitis C virus (HCV) antibodies and allocated to a HCV+ or HCV- group. Skin AF of the healthy subjects was lower than skin AF in the HD patients (3.13 +/- 0.95 vs 2.2 +/- 0.47; P < 0.001). We calculated the average increase of skin AF in the healthy subjects to be 0.017 arbitrary units per year, being 14 times lower than in HD patients with CVD only and 20 times lower than in HD patients suffering from combined CVD and diabetes mellitus (DM). Multivariate regression analysis showed that AGE accumulation in HD patients can be described by the independent effects of age, DM, CVD and HD vintage. Although inter-cellular adhesion molecule 1 and liver enzymes were elevated in HCV+ HD patie...Continue Reading

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Citations

Mar 13, 2012·Nephrology·Kunying ZhangLi Zuo
Apr 25, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Stefan ArsovAndries J Smit
Jul 15, 2020·International Urology and Nephrology·Seshadri Reddy VarikasuvuBalachandar Thangappazham
Jul 3, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Seshadri Reddy VarikasuvuAparna Varma Bhongir

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