PMID: 9444542Jan 28, 1998Paper

Does hippocampal atrophy on MRI predict cognitive decline? A prospective follow-up study

International Journal of Geriatric Psychiatry
A SwannB Tress

Abstract

To investigate whether the presence of hippocampal atrophy (HCA) on MRI in Alzheimer's disease (AD) leads to a more rapid decline in cognitive function. To investigate whether cognitively unimpaired controls and depressed subjects with HCA are at higher risk than those without HCA of developing dementia. A prospective follow-up of subjects from a previously reported MRI study. Melbourne, Australia. Five controls with HCA and five age-matched controls without HCA, seven depressed subjects with HCA and seven without HCA, and 12 subjects with clinically diagnosed probable AD with HCA and 12 without HCA were studied. They were followed up at approximately 2 years with repeat cognitive testing, blind to initial diagnosis and MRI result. HCA was rated by two radiologists blind to cognitive test score results. Cognitive assessment was by the Cambridge Cognitive Examination (CAMCOG). No significant differences in rate of cognitive decline, mortality or progression to dementia were found between subjects with or without HCA. HCA was not found to be a predictor of subsequent cognitive decline in this series.

Citations

Jan 9, 2004·La Revue de médecine interne·C DumontB Vellas
Feb 22, 2003·NeuroImage·Gaël Chetelat, Jean-Claude Baron
May 7, 2002·The Australian and New Zealand Journal of Psychiatry·A F Jorm
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David C SteffensJames R MacFall
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·I SchweitzerJ O'Brien
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Noor Jehan KabaniHoward Chertkow
Oct 31, 2002·International Journal of Geriatric Psychiatry·Isaac SchweitzerDavid Ames
Nov 28, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shangran QiuVijaya B Kolachalama

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