Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California

Sexually Transmitted Infections
Matthew R BeymerRobert K Bolan

Abstract

Pre-exposure prophylaxis (PrEP) is an effective method for reducing HIV incidence among at-risk populations. However, concerns exist over the potential for an increase in STIs following PrEP initiation. The objective of this study is to compare the STI incidence before and after PrEP initiation within subjects among a cohort of men who have sex with men in Los Angeles, California. The present study used data from patients who initiated PrEP services at the Los Angeles LGBT Center between October 2015 and October 2016 (n=275). A generalised linear mixed model was used with a case-crossover design to determine if there was a significant difference in STIs within subjects 365 days before (before-PrEP period) and 365 days after PrEP initiation (after-PrEP period). In a generalised linear mixed model, there were no significant differences in urethral gonorrhoea (P=0.95), rectal gonorrhoea (P=0.33), pharyngeal gonorrhoea (P=0.65) or urethral chlamydia (P=0.71) between periods. There were modest increases in rectal chlamydia (rate ratio (RR) 1.83; 95% CI 1.13 to 2.98; P=0.01) and syphilis diagnoses (RR 2.97; 95% CI 1.23 to 7.18; P=0.02). There were significant increases in rectal chlamydia and syphilis diagnoses when comparing the per...Continue Reading

References

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Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
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Feb 5, 2015·The New England Journal of Medicine·Jeanne M MarrazzoUNKNOWN VOICE Study Team
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Citations

Apr 10, 2019·JAMA : the Journal of the American Medical Association·Michael W TraegerUNKNOWN PrEPX Study Team
Oct 18, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kira L NewmanFerric C Fang
Aug 31, 2019·Journal of the International AIDS Society·Cornelis A Rietmeijer
Nov 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christina SchumacherUNKNOWN IMPACT Partner Collaborative
Jan 30, 2020·International Journal of STD & AIDS·Ronnie M GravettEllen F Eaton
Mar 15, 2019·Sexually Transmitted Infections·Étienne Meunier, Karolynn Siegel
Jul 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose A SerpaHongyu Miao
Oct 20, 2018·Sexually Transmitted Infections·Sebastiaan H HulsteinMaarten F Schim van der Loeff
Feb 16, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Garrett PrestageFengyi Jin
Jun 12, 2019·Current HIV/AIDS Reports·Meena S Ramchandani, Matthew R Golden
Nov 12, 2019·The Journal of Clinical Investigation·Eileen P ScullyJoel N Blankson
Oct 24, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M JanierR Patel
Oct 29, 2020·BMC Infectious Diseases·Camille RollandPénélope Troude
Jun 21, 2021·Survey of Ophthalmology·João M FurtadoJustine R Smith

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