PMID: 9170479Jun 1, 1997Paper

Does hormone replacement therapy inhibit coronary artery calcification?

Obstetrics and Gynecology
J ShemeshM Motro

Abstract

To determine the association between the use of hormone replacement therapy (HRT) and coronary calcium, in postmenopausal women who had no history of coronary artery disease by double helical computed tomography (CT). We used CT to compare the prevalence and extent of coronary calcium in 41 postmenopausal women who were on HRT from the first year of menopause and 37 age-matched controls who had never used HRT. Both groups had a similar rate of smoking, hypertension, a positive family history, and hypercholesterolemia. Coronary calcification was observed in 28.2% of the 78 women studied. The prevalence of coronary calcium was significantly lower among HRT users: six of the 47 (14.6%), compared with 16 of the 37 nonusers (43.2%) (P < .01). The recorded risk factors had no effect on the prevalence of coronary calcium. Stepwise logistic regression analysis, including age, coronary risk factors, and HRT use as independent variables, yielded HRT as the only variable determining the presence of coronary calcium (odds ratio = 0.2; 95% confidence interval 0.06, 0.63; P = .006). The lower incidence of coronary calcium in the HRT users suggests that HRT is associated with decreased prevalence of the coronary calcification.

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Citations

Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Enrique F SchistermanHoward Lewin
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·M G Jakoby, C F Semenkovich
May 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Moeen AbedinLinda L Demer
Feb 17, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ewa Rzewuska-LechVirginia M Miller
Sep 26, 2003·Calcified Tissue International·L B TankòC Christiansen
Jan 26, 2005·Menopause : the Journal of the North American Menopause Society·Elizabeth Barrett-Connor, Gail A Laughlin
Mar 9, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vassiliki PapagianniGeorge Creatsas
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·R C Christian, L A Fitzpatrick
Dec 1, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A Pines, E Z Fisman

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