PMID: 9536881Apr 16, 1998Paper

Does Horner's syndrome in infancy require investigation?

The British Journal of Ophthalmology
N D GeorgeC S Hoyt

Abstract

To evaluate whether isolated Horner's syndrome presenting in the first year of life warrants investigation. Retrospective review of 23 children presenting with Horner's syndrome in the first year of life. In 16 patients (70%) no cause was identified. Birth trauma was the most common identifiable cause (four patients). Twenty one children (91%) had urinary vanillylmandelic acid (VMA) measured and 13 patients (57%) underwent either computed tomography or magnetic resonance imaging of the chest and neck. These investigations revealed previously undisclosed pathology in only two--one ganglioneuroma of the left pulmonary apex and one cervical neuroblastoma. A further patient was known to have abdominal neuroblastoma before presenting with Horner's syndrome. There were no cases of Horner's syndrome occurring after cardiothoracic surgery. Long term follow up of the patients (mean 9.3 years) has not revealed further pathology. Routine diagnostic imaging of isolated Horner's syndrome in infancy is unnecessary. Infants should be examined for cervical or abdominal masses and involvement of other cranial nerves. If the Horner's syndrome is truly isolated then urinary VMA levels and follow up in conjunction with a paediatrician should detec...Continue Reading

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Citations

Mar 10, 2010·Archives of Ophthalmology·Stephen J SmithBrian G Mohney
Feb 26, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Yehoshua AlmogAnat Kesler
Feb 26, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jonathan D Trobe
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Dec 21, 2017·ACS Chemical Neuroscience·Timothy J Martin

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