PMID: 7581588Jan 1, 1995Paper

Does HRT modify risk of gynecological cancers?

International Journal of Fertility and Menopausal Studies
H P Schneider, M Birkhauser

Abstract

A substantial body of recent experimental, clinical and epidemiological evidence indicates that hormones play a major role in the etiology of several human cancers. The ability of hormones to stimulate cell division in certain target organs such as the breast, endometrium, prostate and the ovary, may lead following repeated cell divisions to accumulation of random genetic errors that ultimately produce the neoplastic phenotype. Hormone-related cancers account for more than 30% of all newly diagnosed female cancers in the United States. While most non-hormone-dependent adult cancers rise continuously with age, hormone-responsive cancers of the breast, the ovary and the endometrium rise with age until menopause, and then distinctly level off to a plateau. These epidemiologic characteristics may indicate that the key etiologic events for these cancers occur in the premenopausal period. Prevention strategies that intervene during the premenopausal period can be expected to have a greater long-term impact in reducing risk than those implemented for an equivalent length of time in the postmenopausal years. Epidemiological studies demonstrate a reduction in endometrial cancer risk of about 11.7% per year of combination oral contracept...Continue Reading

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