Does human papillomavirus-negative condylomata exist?

Virology
Laila Sara Arroyo MührEmilie Hultin

Abstract

Condylomata acuminata is caused by human papillomavirus (HPV). PCR with consensus primers will typically detect HPV in >96% of condylomata. Metagenomic sequencing has found that some "HPV-negative" condylomata do indeed contain HPV. We wished to perform a renewed evaluation of the "HPV-negative" condylomata using deeper metagenomics sequencing. Sequencing of whole genome amplified DNA from 40 apparently "HPV-negative" condylomata detected HPV in 37/40 specimens. We found 75 different HPV types, out of which 43 represented novel putative HPV types. Three types were cloned and established as HPV types 200, 201 and 202. Molluscum contagiosum virus was detected in 24 of the 40 samples. In summary, deep sequencing enables detection of HPV in almost all condylomata. "HPV-negative" condylomata might largely be explained by clinical misdiagnosis or the presence of viral variants, distantly related HPV types and/or low viral loads.

References

Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·L GissmannH zur Hausen
Mar 1, 1997·The Journal of Pathology·J M Walboomers, C J Meijer
Jun 18, 2003·The Journal of General Virology·Annika AntonssonBengt Göran Hansson
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Sep 18, 2007·The Journal of General Virology·Ola Forslund
Jul 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·François AubinUNKNOWN EDiTH Study Group
Jan 16, 2009·Journal of Clinical Microbiology·Anna Söderlund-StrandJoakim Dillner
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Mar 9, 2010·Virology·Hans-Ulrich BernardEthel-Michele de Villiers
Jun 2, 2011·International Journal of Cancer. Journal International Du Cancer·Johanna EkströmJoakim Dillner
Mar 1, 2012·International Journal of STD & AIDS·C CastronovoA F Nikkels
Jul 11, 2013·PloS One·Davit BzhalavaJoakim Dillner
Aug 13, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L Sara ArroyoJoakim Dillner
Nov 12, 2013·Virology·Johanna EkströmJoakim Dillner
Jul 25, 2014·Scientific Reports·Davit BzhalavaEmilie Hultin
Jan 13, 2015·Virology·Davit BzhalavaJoakim Dillner

❮ Previous
Next ❯

Citations

Mar 20, 2016·The British Journal of Dermatology·M L Siegenbeek van HeukelomK D Quint
Aug 2, 2019·The American Journal of Surgical Pathology·Iryna V Samarska, Jonathan I Epstein
Dec 21, 2019·The Journal of General Virology·Laila Sara Arroyo MührJoakim Dillner
Aug 11, 2020·PloS One·Laila Sara Arroyo MührJoakim Dillner
Apr 9, 2020·BMC Infectious Diseases·Elisa M BolattiAdriana A Giri
Jun 1, 2019·PloS One·Emilie HultinJoakim Dillner
Dec 29, 2017·Virus Genes·Noé Escobar-EscamillaJosé Alberto Díaz-Quiñonez
Sep 27, 2018·BMC Bioinformatics·Zurab BzhalavaJoakim Dillner
Oct 7, 2020·British Journal of Cancer·Laila Sara Arroyo MührJoakim Dillner
Apr 6, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura SicheroUNKNOWN Ludwig-McGill Cohort Study
Mar 18, 2021·Virology·Laila Sara Arroyo MührJoakim Dillner
May 16, 2021·International Journal of Cancer. Journal International Du Cancer·Laila Sara Arroyo MührJoakim Dillner
Sep 24, 2021·Scientific Reports·Laila Sara Arroyo MührEmilie Hultin
Nov 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Andreina FernandesRene Pareja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Related Papers

Sŭvremenna medit︠s︡ina
A KARPAROV
The Journal of Infection
K Birthistle, D Carrington
Molecular and Cell Biology of Human Diseases Series
C D PorterL C Archard
© 2021 Meta ULC. All rights reserved