Abstract
In a previous haemodynamic examination, 44 young men (18-22 years) with blood pressure elevation above the 98th percentile, mean arterial blood pressure (MAP) greater than or equal to 95 +/- 6 mm Hg, showed an increased cardiac index (dye-dilution) and an enhanced resistance at maximal vasodilation of the hand (venous occlusion plethysmography during hyperaemia). This latter finding suggested arteriolar wall hypertrophy. However, the subgroup with the highest cardiac index (greater than or equal to 3.86 1 min-1 x m2) (n = 18) displayed normal vascular resistance at maximal dilation in comparison with the normotensive control group (n = 29). Consequently, functional signs of arteriolar hypertrophy were restricted to individuals with normal or low cardiac index. At the re-investigation 5 years later, a significant reduction in blood pressure was observed in the normotensive control group (MAP: from 88 +/- 7 to 85 +/- 7 mm Hg, P less than 0.05). There was no change in individuals with initially elevated blood pressure. Furthermore, cardiac index fell significantly with time in this latter group. Thus, the blood pressure elevation in the hypertensive group, previously mainly dependent on high blood flow was, 5 years later, more rel...Continue Reading
References
Oct 31, 1975·The American Journal of Cardiology·S Julius, M Esler
Nov 2, 1979·Klinische Wochenschrift·A Distler, T Philipp
Mar 1, 1978·The American Journal of Medicine·Y A WeissP M Milliez
Jan 1, 1978·Acta Medica Scandinavica·O AndersonL Wilhelmsen
Jun 1, 1975·Circulation Research·S JuliusJ Bennett
Jan 1, 1985·Heart and Vessels. Supplement·N MatsumotoK Hirosawa
Aug 1, 1968·Circulation·S Julius, J Conway
Aug 1, 1969·Circulation Research·T G Coleman, A C Guyton
Aug 1, 1966·Circulation·R H EichR H Lyons
Dec 1, 1980·Clinical Science·P Lund-Johansen
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·F C Reubi, P Weidmann
Oct 1, 1980·Cardiovascular Research·S A Lundin, M Hallbäck-Nordlander
Oct 1, 1960·Annals of Surgery·T DRAPANASJ D STEWART
Jan 1, 1960·Physiological Reviews·E D FREIS
Nov 9, 1963·Lancet·J M LEDINGHAM, R D COHEN
Jan 1, 1936·The Journal of Clinical Investigation·M Prinzmetal, C Wilson
Citations
Apr 1, 1992·The American Journal of the Medical Sciences·N M Kaplan
May 28, 2014·Clinical Physiology and Functional Imaging·Morten B SvendsenNiels H Buus
Feb 21, 2009·American Journal of Hypertension·Francesca SaladiniUNKNOWN HARVEST Study Group
May 1, 1991·Hypertension·M B SuurkülaR Sivertsson
Nov 1, 1992·Hypertension·B R WidgrenO K Andersson
Nov 1, 1994·Hypertension·W S PostD Levy
Jul 29, 2003·Psychosomatic Medicine·Pei-Shan TsaiHossein Yarandi
Jan 6, 2018·Journal of Hypertension·Niels Henrik BuusKarin Skov
Mar 18, 2005·Blood Pressure·Ove K AnderssonBengt R Widgren