Does hypersensitivity to multiple drugs really exist?

Annales de dermatologie et de vénéréologie
Myriam StuderAnnick Barbaud

Abstract

Multiple-drug hypersensitivity (MDH) in the literature concerns different entities. Our objective was to define its frequency and characteristics in patients examined for cutaneous adverse drug reaction (CADR) before studying genetic predisposition. From a database comprising all patients referred for CADR between 2000 and 2010, we selected those meeting the following criteria: sensitisation to at least two chemically unrelated substances, as confirmed by positive skin tests or challenge tests. The following were excluded: patients with haematological diseases, HIV or chronic wounds and sensitization to the excipients. Of the 1925 patients included, 11 (0.6%) were classed as polysensitized: eight women and three men, of mean age 62 years, presenting 2.5 episodes of drug hypersensitivity per patient. Four cases of DRESS were noted. The strict criteria stipulated for this study enabled us to select patients with MDH, and to affirm that while it does in fact exist, it seems rare. Compared to polysensitized patients described in the literature, we preferred to distinguish between three groups of MDH: one occurring with different substances in separate episodes of CADR, one occurring with different substances during the same episode...Continue Reading

References

Oct 24, 2003·The New England Journal of Medicine·Brian L StromDan Pettitt
Sep 2, 2008·Contact Dermatitis·Berit Christina CarlsenJeanne Duus Johansen
Jan 6, 2009·The British Journal of Dermatology·J WatonA Barbaud
Aug 27, 2010·Science Translational Medicine·Damien PicardPhilippe Musette
Dec 21, 2010·Contact Dermatitis·Axel SchnuchKristian Reich

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Citations

Apr 18, 2014·Current Allergy and Asthma Reports·Annick Barbaud
Nov 10, 2012·The British Journal of Dermatology·A BarbaudUNKNOWN Toxidermies group of the French Society of Dermatology
Mar 21, 2017·International Archives of Allergy and Immunology·Werner J PichlerOliver Hausmann
Sep 14, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C PonvertJ de Blic
Nov 7, 2019·Current Pharmaceutical Design·Aslı GelincikSemanur Kuyucu
Nov 8, 2019·Current Pharmaceutical Design·Marcel Bergmann, Jean-Christoph Caubet
Jun 27, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Quentin LandryAnca-Mirela Chiriac
Mar 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Angèle SoriaUNKNOWN FISARD group

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