Does inclusion of a placebo arm influence response to active antidepressant treatment in randomized controlled trials? Results from pooled and meta-analyses

The Journal of Clinical Psychiatry
Mark SinyorKrista L Lanctôt

Abstract

To determine if the inclusion of a placebo arm and/or the number of active comparators in antidepressant trials influences the response rates of the active medication and/or placebo. Searches of MEDLINE, PsycINFO, and pharmaceutical Web sites for published trials or trials conducted but unpublished between January 1996 and October 2007. 2,275 citations were reviewed, 285 studies were retrieved, and 90 were included in the analysis. Trials reporting response and/or remission rates in adult subjects treated with an antidepressant monotherapy for unipolar major depression were included. The primary investigator recorded the number of responders and/or remitters in the intent-to-treat population of each study arm or computed these numbers using the quoted rates. Poisson regression analyses demonstrated that mean response rate for the active medication was higher in studies comparing 2 or more active medications without a placebo arm than in studies comparing 2 or more active medications with a placebo arm (65.4% vs 57.7%, P < .0001) or in studies comparing only 1 active medication with placebo (65.4% vs 51.7%, P = .0005). Mean response rate for placebo was significantly lower in studies comparing 1 rather than 2 or more active medi...Continue Reading

Citations

Apr 17, 2013·Der Schmerz·M Ujeyl, B Müller-Oerlinghausen
Mar 5, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Wan SunYaning Wang
Jun 5, 2012·Journal of Affective Disorders·Verena HenkelHans-Jürgen Möller
Sep 14, 2012·Psychological Medicine·B R RutherfordS P Roose
Aug 23, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Boadie W DunlopPhilip T Ninan
Jul 19, 2013·Translational Psychiatry·D BorsookM Fava
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul EnckStephan Zipfel
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin MeissnerLuana Colloca
Jan 11, 2013·BMJ : British Medical Journal·An-Wen ChanDavid Moher
Dec 22, 2010·Journal of Psychiatry & Neuroscience : JPN·Stefano PorcelliAlessandro Serretti
Dec 21, 2010·Journal of Psychiatry & Neuroscience : JPN·Simon N Young
Jun 12, 2013·Journal of Medical Ethics·Azgad Gold, Pesach Lichtenberg
Oct 18, 2011·Der Nervenarzt·S LeuchtJ M Davis
Dec 17, 2010·Expert Review of Medical Devices·Andre Russowsky BrunoniFelipe Fregni
Mar 19, 2013·Complementary Therapies in Medicine·Paul Enck, Sibylle Klosterhalfen
Dec 30, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eduara Vieta, Nuria Cruz
Mar 19, 2013·Pharmacotherapy·Sergio De FilippisPaolo Girardi
Sep 17, 2013·International Journal of Methods in Psychiatric Research·Florian NaudetBruno Falissard
Jul 4, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V KotsisS Elsenbruch
Jul 31, 2013·Alcoholism, Clinical and Experimental Research·Raye Z LittenHsiao-ye Yi
Feb 19, 2016·Expert Review of Neurotherapeutics·Tom Bschor, Laura L Kilarski
Jan 21, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hans-Jürgen MöllerHans Eriksson
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Irving Kirsch
Sep 27, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Arif Khan, Walter A Brown
Nov 18, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·W M Michael SchüpbachGünther Deuschl
Jul 15, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·P CuijpersU Hegerl
Sep 6, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shinichiro NakajimaMasaru Mimura
Nov 22, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Emanuel SeverusHans-Jürgen Möller
Mar 31, 2015·The Lancet. Psychiatry·Katja WeimerPaul Enck
Aug 19, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Monique A PimontelJoel R Sneed
Mar 6, 2012·Journal of Affective Disorders·Bret R RutherfordSteven P Roose
Jun 7, 2011·Journal of Affective Disorders·Ulrich HegerlRoland Mergl
Sep 13, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Andrew F LeuchterIan A Cook

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.