Does increased baseline ventilation heterogeneity following chest wall strapping predispose to airway hyperresponsiveness?

Journal of Applied Physiology
David G ChapmanC M Salome

Abstract

Baseline ventilation heterogeneity is associated with airway hyperresponsiveness (AHR) in asthma; however, it is unknown whether increased baseline ventilation heterogeneity leads to AHR or both are independent effects of similar disease pathophysiology. Reducing functional residual capacity (FRC) in healthy subjects increases baseline ventilation heterogeneity and airway responsiveness, but the relationship between the two is unclear. The aim was to determine whether an increase in baseline ventilation heterogeneity due to a reduction in FRC correlated with the increase in response to methacholine. In 13 healthy male subjects, ventilation heterogeneity was measured by multiple-breath N(2) washout before a cumulative high-dose (0.79-200 μmol) methacholine challenge. On a separate day, the protocol was performed with chest wall strapping (CWS) to reduce FRC. Indexes of ventilation heterogeneity in the convection-dependent (Scond) and diffusion-convection-dependent (Sacin) airways were calculated from the multiple-breath N(2) washout. CWS decreased FRC by 15.6 ± 2.7% (P < 0.0001). CWS increased the percent fall in forced expiratory volume in 1 s during bronchial challenge (P = 0.006), and the magnitude of this effect was independ...Continue Reading

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Citations

Jun 19, 2013·Respiratory Physiology & Neurobiology·Baoshun MaJason H T Bates
May 14, 2014·American Journal of Respiratory and Critical Care Medicine·Ali Al-AlwanAnne E Dixon
Aug 21, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·David G ChapmanAnne E Dixon
May 16, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W Gerald TeagueTalissa A Altes
Jul 13, 2016·Immunology and Allergy Clinics of North America·Jacqueline O'TooleDavid A Kaminsky
Jul 6, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·David A KaminskyDavid G Chapman
Aug 5, 2017·Clinical and Translational Medicine·Justin K Lui, Kenneth R Lutchen

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