Does increasing life expectancy affect competing mortality after radical prostatectomy?

Urologic Oncology
Michael FroehnerMarkus Graefen

Abstract

In Germany, between 1991 to 1993 and 2004 to 2006, the life expectancy in men increased by 4.2 years with greater gains in the eastern part of the country. In this study, we investigated to which degree this life-expectancy increase was translated into lower competing mortality rates after radical prostatectomy. The study sample comprised 6,831 consecutive patients who underwent radical prostatectomy at the Department of Urology of the Dresden University of Technology and the Department of Urology of the University of Hamburg/Martini Clinic in the years 1992 to 2005. The median age was 63.0 years and the median follow-up was 8.6 years. Three time periods (1992-1995, 1996-2001, and 2002-2005) were compared. Competing mortality was the study end point. Rates after 8 years were used for comparison. Comparisons of mortality rates were made with the 2-sided Wald test. The 8-year competing mortality rates decreased from 7.6% (1992-1995) via 5.6% (1996-2001) to 4.7% (2002-2005 vs. 1992-1995; P = 0.0127). When deaths due to unknown causes (92 of 969 deaths) were considered as non-prostate cancer competing deaths, the corresponding figures were 9.0 % (1992-1995), 6.5% (1996-2001), and 5.6% (2002-2005) vs. 1992 to 1995; P = 0.0107. The e...Continue Reading

References

Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William L ReadJay F Piccirillo
Jan 9, 2007·Urologic Oncology·Michael FroehnerManfred P Wirth
Sep 27, 2008·Annual Review of Medicine·Felipe SierraRichard Hodes
Oct 6, 2009·Lancet·Kaare ChristensenJames W Vaupel
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Mar 24, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·G DoblhammerA Dethloff
Mar 12, 2013·European Urology·Elizabeth D SelvaduraiChris C Parker

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Citations

Mar 5, 2015·European Urology·Hartwig Huland, Markus Graefen
Aug 17, 2019·Clinical Genitourinary Cancer·Sophie KnipperPierre I Karakiewicz

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