Does indomethacin antagonize the effects of peptides and other agents on the coronary circulation of rabbit isolated hearts

Canadian Journal of Physiology and Pharmacology
D RegoliB Thériault


The coronary vasodilator effects of substance P, bradykinin, eledoisin, adenosine, and nitroglycerin have been tested in rabbit isolated hearts perfused with physiological medium. It has been found that substance P is the most potent vasodilator and that the peptides are 10-100 times as active as adenosine and nitroglycerin. The effect of bradykinin is reduced by 50% in the presence of indomethacin (2.8-5 X 10(-6) M) while the actions of the other vasodilator are not influenced. At such concentrations, indomethacin is inactive on its own and blocks the effects of small and intermediate doses of arachidonic acid, the prostaglandin precursor. It suggested that edogenous prostaglandins do not play any major role in mediating the coronary vasodilation produced by several peptide and nonpeptide agents, but may account for about 50% of the effect of bradykinin.


Apr 24, 1981·European Journal of Pharmacology·D RegoliJ Lavigne
Jan 27, 1984·European Journal of Pharmacology·D RegoliJ Mizrahi
Jan 13, 1990·Lancet·P Collins, K M Fox
Jan 1, 1987·General Pharmacology·A E Ali
Mar 1, 1988·Progress in Cardiovascular Diseases·E Bassenge, R Busse
Sep 25, 1982·British Medical Journal·A Zezulka, N Wright
Sep 25, 1982·British Medical Journal·T A Betts, J Birtle

Related Concepts

Bradykinin, (3-D-Pro)-Isomer
Coronary Circulation
Saturated Fat
Prostaglandins E
Prostaglandins F
Chinchilla Rabbits
Hypothalamic Substance P

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.