Does influenza pandemic preparedness and mitigation require gain-of-function research?

Influenza and Other Respiratory Viruses
Dillon C AdamC Raina MacIntyre

Abstract

The risk and benefits of gain-of-function studies on influenza A have been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain-of-function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain-of-function research and argue that the anticipated benefits have yet to materialize while the significant risks remain.

References

Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HaD C Wiley
Apr 9, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul K S Chan
Dec 4, 2003·Science·Richard J Webby, Robert G Webster
May 15, 2004·Science·Neil M FergusonRoy M Anderson
Jan 26, 2005·The New England Journal of Medicine·Kumnuan UngchusakSupamit Chunsutthiwat
Oct 18, 2005·Virology·Alexandra GambaryanAlexander Klimov
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Mar 25, 2006·Science·Debby van RielThijs Kuiken
Apr 1, 2006·Glycoconjugate Journal·R J RussellJ J Skehel
Apr 22, 2006·Science·Thijs KuikenBryan T Grenfell
Apr 28, 2006·PLoS Medicine·Ben S CooperNigel J Gay
Nov 25, 2006·The New England Journal of Medicine·I Nyoman KandunTimothy M Uyeki
Jan 9, 2007·Nature Medicine·J M NichollsJ S M Peiris
Jan 27, 2007·PLoS Medicine·Vittoria ColizzaAlessandro Vespignani
Jul 13, 2007·Journal of Virology·Prasert AuewarakulPilaipan Puthavathana
Oct 19, 2007·Journal of Virology·Yiming BaoDavid Lipman
Jan 8, 2008·Nature Biotechnology·Aarthi ChandrasekaranRam Sasisekharan
Feb 7, 2008·Emerging Infectious Diseases·Yang YangIra M Longini
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jessica A BelserTerrence M Tumpey
Jun 16, 2009·Nature·Gabriele NeumannYoshihiro Kawaoka
Oct 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vivek CharuCécile Viboud
Jan 24, 2012·Science·Michael T Osterholm, Donald A Henderson
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peter Palese, Taia T Wang
Mar 1, 2012·MBio·Michael T Osterholm, Nicholas S Kelley
Mar 27, 2012·Current Opinion in Virology·Masaki Imai, Yoshihiro Kawaoka
Mar 29, 2012·The Journal of Infectious Diseases·Michael T Osterholm, David A Relman
Jun 23, 2012·Science·Rino Rappuoli, Philip R Dormitzer
Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Oct 11, 2012·MBio·Marc Lipsitch, Barry R Bloom
Nov 21, 2012·PLoS Pathogens·Gabriele NeumannYoshihiro Kawaoka
Feb 6, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Austin G MeyerClaus O Wilke
Apr 27, 2013·Virus Research·James C Paulson, Robert P de Vries

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