Does intensive follow-up alter outcome in patients with advanced lung cancer?

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Rachel BenamoreStephen Herman

Abstract

Despite aggressive multimodality treatment, 5-year survival of stage III non-small cell lung cancer (NSCLC) remains <30%. To detect relapse, progression, or development of a second primary cancer early, many clinicians perform follow-up scans. To assess the impact of routine scanning, we compared clinical trial patients who had study-mandated scans with those treated off-study who had less intensive radiologic follow-up. The hospital cancer registry and trials databases were searched for patients with locally advanced NSCLC who had undergone multimodality treatment with curative intent. Baseline demographics were collected as well as frequency and results of clinical and radiologic follow-up. Forty trial patients and 35 nontrial control patients were identified. Trial patients underwent significantly more imaging, particularly in the first 2 years (2.9 versus 2.0 body scans per year, p = 0.0016; 1.1 versus 0.4 brain scans per year, p < 0.001) but did not have more frequent follow-up visits. Forty-five cancers were detected (41 relapses, four metachronous primary tumors) in 44 (59%) patients. Of these, 28 (64%) sought medical attention that led to detection before a scheduled appointment or procedure. There was no significant di...Continue Reading

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Citations

Oct 6, 2014·The Annals of Thoracic Surgery·Leah M BackhusDavid R Flum
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lynn CalmanMyfanwy Lloyd-Jones
Feb 16, 2011·Cancer Treatment Reviews·Judith van LoonDirk De Ruysscher
Dec 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Judith van LoonDirk De Ruysscher
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Aug 2, 2015·The Journal of Surgical Research·Leah M BackhusSteven B Zeliadt
Sep 15, 2014·The Journal of Thoracic and Cardiovascular Surgery·Traves D CrabtreeBryan Meyers
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew J FurmanGiles F Whalen
Jul 14, 2016·Journal of Oncology Practice·Rafael Santana-Davila, Renato G Martins
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Sep 5, 2017·Surgical Neurology International·Kaleigh FetckoMahua Dey
Feb 15, 2019·Asia-Pacific Journal of Clinical Oncology·Sharanya MohanShalini Vinod
Jul 10, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Martina ImbimboPaolo Bossi
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Oct 28, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jenny MitchellElizabeth Belcher

Related Concepts

Non-Small Cell Lung Carcinoma
Clinical Trials
Combined Modality Therapy
Malignant Neoplasm of Lung
Neoplasm Invasiveness
Neoplasm Recurrence, Local
TNM Staging System
Probability
Retrospective Studies
Tomography, X-Ray Computerized Axial

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