PMID: 9448209Feb 3, 1998Paper

Does intermittent "pulse" topical 5-fluorouracil therapy allow destruction of actinic keratoses without significant inflammation?

Journal of the American Academy of Dermatology
E Epstein

Abstract

Topical 5-fluorouracil (5-FU) is effective in removing actinic keratoses but causes unsightly and painful erosions. Intermittent "pulse" 5-FU therapy has been described as being an effective and comfortable technique for destroying actinic keratoses. The purpose of this study was to determine the efficacy and cutaneous side effects of intermittent 5-FU therapy. Efficacy of treatment was evaluated by three experienced dermatologists separately comparing randomly arranged before and after photographs. Degree of skin reaction was graded from photographs taken during treatment. Of 13 patients treated with intermittent 5-FU, two had an excellent result, three a good result, but eight failed to show discernible improvement. Efficacy was linked to the degree of skin irritation. Pulse 5-FU failed to clear actinic keratoses in most patients. Intermittent 5-FU treatment does not dissociate its therapeutic efficacy from its undesirable erosive effects. Pulse therapy is a less intensive way of employing 5-FU and may be of value in patients unwilling to accept the erosions and discomfort that accompany the traditional course of daily 5-FU applications.

References

Jun 1, 1981·Journal of the American Academy of Dermatology·D K Goette
Oct 1, 1995·Journal of the American Academy of Dermatology·J D WhitedD L Simel
Jun 1, 1994·Journal of the American Academy of Dermatology·R S SternK A Arndt

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Citations

Feb 14, 2002·The British Journal of Dermatology·J K RiversY Poulin
Dec 12, 2001·International Journal of Dermatology·J E WolfS Kang
Apr 2, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Javier LabandeiraJaime Toribio
Nov 1, 2013·Anais Brasileiros De Dermatologia·Luís Antônio Ribeiro Torezan, Cyro Festa-Neto
Jan 1, 2010·Clinical, Cosmetic and Investigational Dermatology·Joshua M Berlin
Nov 13, 2001·American Journal of Clinical Dermatology·E W Jeffes, E H Tang
Jun 10, 2004·American Journal of Clinical Dermatology·Ernst Epstein
Jan 25, 2005·American Journal of Clinical Dermatology·Bryan A Lober, Neil A Fenske
Feb 24, 2006·American Journal of Clinical Dermatology·Angela J WyattDana L Sachs
Nov 7, 2008·Cutaneous and Ocular Toxicology·Miranda A FarageHoward I Maibach
Jan 17, 2007·The British Journal of Dermatology·D de BerkerUNKNOWN British Association of Dermatologists Therapy Guidelines and Audit Subcommittee
Dec 9, 2004·Seminars in Cutaneous Medicine and Surgery·S Teri McGillis, Howard Fein
Oct 6, 2011·Journal of Experimental & Clinical Cancer Research : CR·Kaori KadoyamaYasushi Okuno
Jan 8, 2000·Dermatologic Clinics·N Lawrence
May 31, 2007·The Australasian Journal of Dermatology·Cara HolmesAlvin H Chong
Oct 23, 2010·The Journal of Dermatological Treatment·Hadas SkupskyGary Goldenberg
Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes
Nov 1, 2016·The Journal of Dermatological Treatment·Thomas DirschkaGiovanni Pellacani
Aug 8, 2009·International Journal of Dermatology·Ediléia BagatinSergio Talarico
Feb 13, 2003·The Australasian Journal of Dermatology·Kurt GebauerGeorge Varigos
Dec 3, 2003·Seminars in Cutaneous Medicine and Surgery·Sirunya SilapuntMurad Alam
Nov 11, 2003·Comprehensive Therapy·Pearon G Lang
Sep 22, 2020·The Journal of Investigative Dermatology·Barbara A Gilchrest
Jun 11, 2021·The British Journal of Dermatology·S AhmadyK Mosterd

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