PMID: 9426014Jan 13, 1998Paper

Does intracoronary thrombus influence the outcome of high risk percutaneous transluminal coronary angioplasty? Clinical and angiographic outcomes in a large multicenter trial. EPIC Investigators. Evaluation of IIb/IIIa Platelet Receptor Antagonist 7E3 in Preventing Ischemic Complications

Journal of the American College of Cardiology
M M KhanN S Kleiman

Abstract

We sought to evaluate the impact of angiographically visible thrombus on short- and long-term clinical outcomes after percutaneous transluminal coronary angioplasty (PTCA). Intracoronary thrombus is frequently seen on angiography in patients with acute ischemic coronary syndromes or complex lesion morphology, or both, and is often considered to predict a higher rate of complications in patients undergoing PTCA. Prospectively collected data from 2,099 patients undergoing high risk PTCA in the Evaluation of IIb/IIIa Platelet Receptor Antagonist 7E3 in Preventing Ischemic Complications (EPIC) trial were analyzed. In addition to aspirin and heparin, patients were randomized to receive either abciximab bolus and infusion, abciximab bolus alone or placebo. Based on an angiographic core laboratory interpretation, patients were classified into three groups: thrombus absent, thrombus possible or thrombus present. The primary end point at 30 days was the composite of death, myocardial infarction or urgent revascularization. The 6-month end point was the composite of death, myocardial infarction or any revascularization. Although abrupt closure was most common in patients with thrombus present compared with thrombus absent or possible (13...Continue Reading

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Citations

Sep 5, 2002·The American Journal of Cardiology·Stéphane RinfretRoger J Laham
Dec 31, 2002·Journal of the American College of Cardiology·Mario MarzilliSilvio Fedele
Oct 16, 1999·Journal of the American College of Cardiology·V MathewD R Holmes
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Feb 9, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Andrew J Carter, Kenton Gregory
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Aug 31, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Behzad TaghizadehAugustin DeLago
Mar 26, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ran KornowskiAbid Assali
Nov 7, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Robert V KellyGeorge A Stouffer
Nov 7, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gennaro SardellaFrancesco Fedele
Apr 9, 2016·Veterinary World·Tossou Jacques Dougnon, Messanvi Gbeassor
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