Does Intraoperative Cell Salvage Reduce Postoperative Infection Rates in Cardiac Surgery?

Journal of Cardiothoracic and Vascular Anesthesia
Jan van KlarenboschAdrianus J de Vries

Abstract

Primary outcome was the risk for infections after cell salvage in cardiac surgery. Data of a randomized controlled trial on cell salvage and filter use (ISRCTN58333401). Six cardiac surgery centers in the Netherlands. All 716 patients undergoing elective coronary artery bypass grafting, valve surgery, or combined procedures over a 4-year period who completed the trial. Postoperative infection data were assessed according to Centre of Disease Control and Prevention/National Healthcare Safety Network surveillance definitions. Fifty-eight (15.9%) patients with cell salvage had infections, compared with 46 (13.1%) control patients. Mediation analysis was performed to estimate the direct effect of cell salvage on infections (OR 2.291 [1.177;4.460], p = 0.015) and the indirect effects of allogeneic transfusion and processed cell salvage blood on infections. Correction for confounders, including age, seks and body mass index was performed. Allogeneic transfusion had a direct effect on infections (OR = 2.082 [1.133;3.828], p = 0.018), but processed cell salvage blood did not (OR = 0.999 [0.999; 1.001], p = 0.089). There was a positive direct effect of cell salvage on allogeneic transfusion (OR = 0.275 [0.176;0.432], p < 0.001), but a n...Continue Reading

References

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Citations

Dec 6, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Daniel BolligerAndreas Buser
Aug 22, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Saurabh GuptaRichard Whitlock

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