Does intratesticular testosterone administration modify the evolution of transitory testicular ischemia in pre-pubertal rats?

The Journal of Urology
C T Da RosA Hartmann

Abstract

Testicular torsion followed by ischemia results in variable degrees of infertility and until now there appears to be no effective way to recover it. Testosterone participation in the maintenance of male sexual organs and spermatogenesis led us to hypothesize that intratesticular administration could recover ischemic injury. We divided 40 Wistar rats in 2 groups, of 20 each. One group was control and the other underwent a 120-minute testicular ischemia by means of a vascular clamp on the left spermatic cord. Each group was further subdivided in 2 subgroups. The first one was observed and the second received intratesticular testosterone 25 mg. starting on the third day after injury and during the next 7 consecutive days. Half the animals were sacrificed 30 days after injury and the remaining ones after 60 days. Weight, volume, number of seminiferous tubules, histology and spermatogenesis of the same side and contralateral testes were examined. For statistical analysis ANOVA and Fisher's tests were applied. It was found that testosterone was capable of acting upon volume and weight of the left testis (p=0.0001). The animals receiving intratesticular testosterone showed lower testicular weight and volume after 30 and 60 days, respe...Continue Reading

References

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Citations

Jun 15, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Salih SomuncuMurat Kaya
Dec 3, 2014·Fertility and Sterility·Edmund Y KoAshok Agarwal
May 25, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shogo ShimizuMotoaki Saito

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