Abstract
1. The autonomic nervous system plays a pivotal role in modulating all the components of the cardiovascular regulation. Therefore, one can assume that drugs targeting this system may be useful in the management of several cardiovascular diseases. 2. Drugs acting on central nervous system centres seem to be modulators rather than blockers; as such, they are expected to preserve the contraregulatory processes and to generate only a few side effects. 3. Because the sympathetic nervous system is largely involved in the regulation of vasomotor tone, centrally acting antihypertensive drugs were developed first. 4. Recently, new leader compounds selective for non- adrenergic imidazoline recepetors have been synthetized. Although such drugs have no capacity to activate alpha2-adrenoceptors, they have been proven to be hypotensive. These drugs are expected to be even better tolerated than the currently available centrally active drugs. They may also have additional beneficial effects. 5. Here, the experimental evidence suggesting that such drugs may be useful in the management of some cardiac arrhythmias and/or left ventricular dysfunction will be reviewed.
References
Nov 1, 1992·Clinical Pharmacology and Therapeutics·J P McKaigue, D W Harron
Jul 23, 1992·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial II Investigators
Aug 10, 1989·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial (CAST) Investigators
Jan 1, 1987·Pharmacotherapy·A S ManolisJ Nobile
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Mar 1, 1983·The American Journal of Cardiology·J B HermillerC V Leier
Jan 29, 1981·European Journal of Pharmacology·P BousquetJ Schwartz
Dec 1, 1981·Clinical Pharmacology and Therapeutics·T D GilesR L Dillenkoffer
Nov 1, 1995·Hypertension·A J ManolisH Gavras
May 23, 1996·The New England Journal of Medicine·M PackerN H Shusterman
Apr 1, 1996·British Journal of Pharmacology·T MammotoI Yoshiya
Nov 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·J C RoegelP Bousquet
Jan 1, 1997·Hypertension·A J ManolisH Gavras
Mar 1, 1997·Hypertension·M Castellano, M Böhm
Mar 1, 1997·Current Opinion in Cardiology·J B Young
Mar 3, 1998·Lancet·M T La RovereP J Schwartz
Apr 29, 1998·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·C M White
Jul 23, 1999·Annals of the New York Academy of Sciences·V BrubanP Bousquet
Jul 23, 1999·Annals of the New York Academy of Sciences·P BousquetJ Feldman
Dec 14, 1999·Drugs·P Bousquet, J Feldman
Aug 2, 2000·American Journal of Hypertension·R D Brook, S Julius
Sep 12, 2000·Current Hypertension Reports·P Palatini, S Julius
Mar 7, 2001·Hypertension·G Y SyJ Feldman