Does L-carnitine supplementation affect serum levels of enzymes mainly produced by liver? A systematic review and meta-analysis of randomized controlled clinical trials.

European Journal of Nutrition
Farzaneh PirmadahAmin Salehi-Abargouei

Abstract

L-carnitine supplementation is proposed to reduce liver enzymes levels; however, previous findings were equivocal. The current systematic review and meta-analysis of randomized controlled clinical trials (RCTs) were performed to assess the effect of L-carnitine supplementation on serum levels of enzymes mainly produced by liver [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGTP)]. Online databases as well as the reference lists of relevant studies were searched from inception up to June 2019. The risk of bias in individual studies was assessed using Cochrane Collaboration's tool. Data were pooled using the random-effects model and expressed as mean differences (MDs) with 95% confidence intervals (CIs). In total, 18 RCTs (1161 participants) met the eligibility criteria. L-carnitine supplementation dose ranged from 500 to 4000 mg/day. L-carnitine supplementation significantly reduced serum ALT (MD = - 8.65 IU/L, 95% CI - 13.40, - 3.90), AST (MD = - 8.52 IU/L, 95% CI - 12.16, - 4.89), and GGTP (MD = - 8.80 IU/L, 95% CI - 13.67, - 3.92) levels. The subgroup analysis showed that L-carnitine might be more effective in reducing the enzymes when supplemented in higher doses (≥ 200...Continue Reading

References

Sep 1, 1977·The Journal of Clinical Investigation·D RudmanJ D Ansley
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·J G RollasonD Robinson
Jan 21, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·S GeorgalaT Michas
Apr 27, 2000·The New England Journal of Medicine·D S Pratt, M M Kaplan
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Aug 12, 2003·Clinical Pharmacokinetics·Allan M Evans, Gianfranco Fornasini
Apr 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Dec 14, 2004·Annals of the New York Academy of Sciences·Charles J Rebouche
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Oct 29, 2005·Life Sciences·Ilhami Gülçin
Jan 10, 2006·Methods in Enzymology·Hongqiao ZhangJinah Choi
Feb 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C P M S OliveiraF J Carrilho
Apr 8, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Nicola LongoMarzia Pasquali
Oct 17, 2007·Digestive Diseases and Sciences·Marcello RomanoMariano Malaguarnera
Mar 5, 2008·Journal of Child and Adolescent Psychopharmacology·L Eugene ArnoldMichael Manos
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Yoshikazu YoneiToshito Yoshioka
Aug 19, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine E LynchSteven M Brunelli
Jul 22, 2009·Expert Opinion on Pharmacotherapy·Fabio GalvanoMariano Malaguarnera
Apr 22, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Kathryn WeibrechtSteven B Bird
Jun 24, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chae Young LimJin Hyun Jun
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoGianfranco Pagano
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Elango KathirvelTimothy R Morgan
Feb 12, 2011·The American Journal of Clinical Nutrition·Michele MalaguarneraFabio Galvano
Mar 30, 2011·Scandinavian Journal of Gastroenterology·Mariano MalaguarneraGiovanni Pennisi
Jun 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·David A GeierMark R Geier
Oct 25, 2011·Molecular Aspects of Medicine·Cesare IndiveriFerdinando Palmieri
Nov 9, 2011·Free Radical Biology & Medicine·Anabela P RoloCarlos M Palmeira
Feb 16, 2012·Current Opinion in Gastroenterology·Mariano Malaguarnera

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Citations

Aug 25, 2021·Journal of Biomaterials Science. Polymer Edition·Xueyan HouXiao Wang

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