Does lead provoke the peroxidation process in rat brain synaptosomes?

Molecular and Chemical Neuropathology
B Dabrowska-BoutaU Rafałowska

Abstract

Up to now there has been no information concerning the effect of lead on the peroxidation process in brain nerve endings. We have examined whether lead acetate (in chronic and acute models of toxicity in vivo and in vitro) affected the level of free radicals in synaptosomes obtained from rat brain. Simultaneously, we have checked the effect of peroxidation of Pb2+ on brain homogenates and microsomal fraction. Our results indicated that the lead level in synaptosomal fraction obtained from lead-treated rats was much higher than in controls. We did not observe induction of spontaneous and Fe(3+)-dependent peroxidation either in synaptosomes or in homogenates and brain microsomes after chronic and acute lead administration to the rats. Lead itself also did not enhance both processes when added in vitro to the control brain synaptosomes in micromolar concentrations. The lack of the lead effect on the peroxidation process in subcellular fractions of brain was rather surprising, because lead is known to be the accelerator of Fe(3+)-dependent peroxidation processes in liver. Additionally, livers from rats under the same toxicity conditions were examined. We have found that lead did not provoke spontaneous peroxidation in liver, but co...Continue Reading

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Citations

Aug 1, 1997·Molecular and Chemical Neuropathology·L StruzyńskaU Rafałowska
Apr 12, 2011·Biological Trace Element Research·Ahmed E Abdel MoneimSaleh Al-Quraishy
Oct 1, 1996·Toxicology Letters·S C Bondy, S X Guo
Mar 20, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Irena Baranowska-Bosiacka, Alina Joanna Hlynczak
Jan 5, 2002·Journal of Toxicology and Environmental Health. Part a·R Mateo, D J Hoffman
Jan 26, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M F CasadoR Cecchini

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