Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells?

Antioxidants & Redox Signaling
Junying WangAkihiro Morikawa

Abstract

Leukotrienes (LTs) are one of the most important mediators in the pathophysiology of asthma. We measured the intracellular amounts of reduced glutathione (GSH) and oxidized glutathione (GSSG) in cultured human airway epithelial cells. LTC 4 affects the GSH/GSSG ratio by activating signals to increase interleukin-8 (IL-8) production. Pretreatment with a reducing agent, glutathione monochrome ester (GSH-OEt), and with a leukotriene receptor antagonist, montelukast, significantly suppressed LTC(4)-induced time-dependent changes in the intracellular redox state, and also suppressed upregulation of IL-8 production by suppressing NF-kappaB activation. Our observations led to the hypothesis that LTC(4)-induced oxidative stress is likely to contribute to amplification of airway inflammation.

References

Nov 1, 1992·The Journal of Clinical Investigation·L E DeForgeD G Remick
Jan 1, 1991·Experimental Lung Research·S L KunkelR M Strieter
Jun 1, 1989·The Journal of Allergy and Clinical Immunology·P J Barnes
Jun 1, 1994·Chemico-biological Interactions·M MeyerP A Baeuerle
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·A BelliniS Mattoli
Oct 1, 1996·International Journal of Experimental Pathology·M M EpperleinN Woolf
Jan 1, 1997·Annual Review of Immunology·H NakamuraJ Yodoi
Jul 1, 1999·American Journal of Respiratory Cell and Molecular Biology·K AoshibaA Nagai
Jun 29, 2002·Cellular and Molecular Life Sciences : CMLS·J Z Haeggström, A Wetterholm
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Adam AntczakPeter J Barnes
Sep 5, 2002·The Journal of Allergy and Clinical Immunology·Russell P Bowler, James D Crapo
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IchiyamaS Furukawa
Oct 28, 2003·American Journal of Respiratory and Critical Care Medicine·Daniel E SloniewskyPeter H S Sporn
Jun 3, 2005·The European Respiratory Journal·P Chanez
Sep 24, 2005·American Journal of Respiratory Cell and Molecular Biology·Diahn-Warng PerngYu-Chin Lee

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Citations

Oct 21, 2011·Inflammation·Kaori SekineHirokazu Arakawa
Jan 8, 2008·Antioxidants & Redox Signaling·Yuma Hoshino, Michiaki Mishima
Aug 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fadhil G Al-AmranAli M Hashim
Jun 12, 2009·The Journal of Surgical Research·Erkan OzkanGöksel Sener

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