Does Magnesium Sulfate as an Adjuvant of Local Anesthetics Facilitate Better Effect of Perineural Nerve Blocks?: A Meta-analysis of Randomized Controlled Trials

The Clinical Journal of Pain
Mengzhu LiZhiqiang Liu

Abstract

To investigate the efficacy and safety of magnesium sulfate as an adjuvant of local anesthetics in perineural nerve blocks. Randomized controlled trials studying the effect and safety of magnesium sulfate in perineural nerve blocks were retrieved from online databases. The mean difference (MD), risk ratio, and their corresponding 95% confidence intervals (CIs) were calculated using RevMan 5.3 statistical software. Seven trials evaluating 493 patients were included. The pooled results from our meta-analysis showed that a combination of magnesium sulfate and local anesthetics in nerve blocks could result in longer postoperative duration time of analgesia (MD=124.66; 95% CI, 65.09-184.23; P<0.0001), longer duration time of sensory (MD=106.69; 95% CI, 60.93-152.45; P<0.00001) and motor block (MD=89.95; 95% CI, 50.89-129.00; P<0.0001). In addition, magnesium sulfate in nerve blocks was also associated with significantly quick onset of motor block (MD=-1.17; 95% CI, -1.73 to -0.60; P<0.0001). For onset time of sensory block, number of patients requiring supplementary analgesics, and incidence of postoperative nausea and vomiting, no statistically differences were observed between the 2 groups. The present study suggests that combined...Continue Reading

References

Feb 1, 1984·Anesthesia and Analgesia·T AkutagawaJ D Katz
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jan 1, 1997·Annales Françaises D'anesthèsie Et De Rèanimation·J E BazinP Schoeffler
Jan 5, 2000·British Journal of Anaesthesia·W J FawcettD A Male
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 29, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Koj JarboNidhi Bidyut Panda
Feb 28, 2007·British Journal of Anaesthesia·A BilirA Ozcelik
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Oct 21, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ae Ryoung LeeSoo Joo Choi
Dec 31, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin G BruceLee V Wesner
Jun 15, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Perihan EkmekciArif Hikmet Suer
Aug 2, 2013·Korean journal of anesthesiology·Sang-Hwan Do
Nov 20, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Santvana KohliPramod Kohli
Apr 2, 2015·Anesthesiology and Pain Medicine·Mohammad HaghighiNasim Ashoori Saheli

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Citations

Feb 18, 2017·Current Pain and Headache Reports·Veerandra KoyyalamudiAlan D Kaye
Jun 1, 2020·Regional Anesthesia and Pain Medicine·Johnny Wei BaiVincent Chan
Oct 8, 2020·Current Opinion in Anaesthesiology·Neel DesaiEric Albrecht
Nov 12, 2020·Journal of Brachial Plexus and Peripheral Nerve Injury·Siavash BeiranvandMaryam Baghizadeh Baghdashti

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