Does magnesium sulfate reduce the short- and long-term requirements for pain relief after caesarean delivery? A double-blind placebo-controlled trial

American Journal of Obstetrics and Gynecology
Michael J PaechJohn P Newnham

Abstract

The purpose of this study was to determine whether magnesium sulfate decreases postoperative pain and analgesic consumption. Women who underwent elective cesarean delivery were randomized into groups according to high-dose magnesium sulfate (50 mg/kg load and 2 g/h), low-dose magnesium sulfate (25 mg/kg load and 1 g/h), or placebo. Before the delivery, the dose of patient-controlled opioid that was used and the visual analogs of pain during the first 48 hours after delivery and at 6 weeks were assessed. Forty-two women were assigned randomly to the high-dose arm; 38 women were assigned to the low-dose magnesium arms, and 40 women were assigned to the control arm. The cumulative opioid use (P = .636); pain scores at 6, 12, 24, and 48 hours at rest (P = .786) and with movement (P = .179); the use of analgesics after hospital discharge (P = .711); and wound pain with movement (P = .429) or pressure (P = .144) after 6 weeks were similar. Magnesium sulfate does not reduce the severity of short-term or long-term (6 weeks) pain after cesarean delivery.

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Citations

Mar 13, 2013·International Journal of Obstetric Anesthesia·R LandauC Ortner
Nov 28, 2012·Journal of Pain and Symptom Management·Vincent CrosbyAndrew Wilcock
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Scott S Reuben, Lakshmi Yalavarthy
Jul 22, 2014·Veterinary Anaesthesia and Analgesia·Anne BahrenbergEva Rioja
Nov 3, 2016·Journal of Anesthesia·Marija S KutlesicTatjana Mostic-Ilic
Nov 26, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magdalena Bujalska-ZadrożnyMarek Naruszewicz
Aug 2, 2013·Korean journal of anesthesiology·Sang-Hwan Do
Sep 6, 2012·Korean journal of anesthesiology·Hanan F KhafagyYasser M Samhan
Jan 16, 2018·Anesthesiology Research and Practice·Andrew McKeownRaymond Hodgson
Mar 9, 2021·Current Anesthesiology Reports·Kishan Patel, Mark Zakowski
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H Y Zhong, W P Zhang

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