Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies

PloS One
Menglin LiShuangqing Zhai

Abstract

To investigate that whether an association between marital status and the female breast cancer risk exists. The MEDLINE, EMBASE and PsycINFO databases were searched from their inception to July 2019. The Newcastle-Ottawa Scale was used to rate the methodological quality of included studies. Study data were pooled using random-effects meta-analyses to compare the breast cancer risk between unmarried, widowed, divorced or lifelong single women and married women. This study is registered with PROSPERO (number CRD42018112368). Forty-nine publications were included in the meta-analysis. Compared with married women, unmarried and lifelong single women had an elevated risk of breast cancer, and the pooled ORs of case-control studies were 1.20 (95% CI: 1.07 to 1.35) and 1.24 (95% CI: 1.05 to 1.45), respectively. In the subgroup analyses under these two comparisons, hospital-based estimates and multivariate-adjusted estimates demonstrated a strong association, while population-based estimates and age-adjusted estimates produced nonsignificant results. The pooled OR of cohort studies examining the effect of being a lifelong single woman was 1.10 (95% CI: 1.04 to 1.16). Heterogeneity was moderate to substantial across case-control studies...Continue Reading

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Citations

Oct 24, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L BovbjergJonathan M Snowden
May 5, 2021·BMC Women's Health·Bonita SalmeronFaustine Williams

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