PMID: 6126399Jun 1, 1982

Does mast cell protection plus mediator antagonism surpass the effect of a classic antihistaminic in the treatment of chronic urticaria? A double-blind comparison of oxatomide and mequitazine

Dermatologica
J DemaubeugeR Broux

Abstract

A new type of antiallergic drug, oxatomide (60 mg daily), was compared with the antihistaminic, mequitazine (10 mg daily), in a 5-week double-blind randomized study involving 26 patients with chronic urticaria. In the 13 oxatomide-treated patients, papules, erythema and pruritus were significantly suppressed after 2 weeks, which was markedly more rapid than with mequitazine. Slight somnolence was reported by 3 patients on oxatomide and 1 on mequitazine; in the latter case, severe urine retention was also reported. Another patient on mequitazine had to discontinue treatment because of severe drowsiness.

Citations

Jan 1, 1986·The Journal of International Medical Research·L HugonotD Beaumont
Jan 1, 1988·British Journal of Clinical Pharmacology·N BrionC Advenier
Sep 1, 2005·Expert Review of Clinical Immunology·B Wedi, A Kapp
Nov 15, 2014·The Cochrane Database of Systematic Reviews·Maulina SharmaBen Carter
Jan 27, 2006·Allergy·T ZuberbierB Wedi
Nov 8, 2013·Expert Opinion on Pharmacotherapy·Michael MakrisT Zuberbier
Sep 24, 2009·Allergy·T ZuberbierWorld Allergy Organization

Related Concepts

Mircol
Tinset
Double-Blind Method
Antihistamines, Classical
Phenothiazines
Piperazines
Randomization
Urticaria

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