Does maternal knowledge and parent education affect blood phenylalanine control in phenylketonuria?

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
Anita MacDonaldA Chakrapani

Abstract

Metabolic control in phenylketonuria (PKU) may be influenced by parental ability because dietary treatment involves complex food choices. This is an observational study to compare maternal carer (MC) knowledge and parental education with phenylalanine concentrations in children with PKU. Children (n = 46; 26 boys) aged 1-10 years (median age 6 years) on dietary treatment were recruited. Their median lifetime and median phenylalanine concentrations in the year prior to study were estimated. MC completed a questionnaire to assess dietary knowledge. Overall maternal knowledge on most aspects of diet was good and there was a correlation between annual median blood phenylalanine concentrations, but at the age of 5-6 years of age only, and higher maternal carer scores on PKU knowledge (r = -0.646; P < 0.0001). Three of only four children (12%) with median phenylalanine concentrations above 500 micromol L(-1) in the year prior to study had both parents leave school without educational qualifications. Children who had median phenylalanine concentrations (n = 3; 7%) over the recommended ranges at 3 years of age or earlier continued to have poor control. Blood phenylalanine control within the first 3 years of age, poor parental education...Continue Reading

References

Apr 1, 1989·Journal of Consulting and Clinical Psychology·A M Fehrenbach, L Peterson
May 1, 1996·Archives of Disease in Childhood·A MacDonaldI W Booth
Mar 1, 1997·Journal of Inherited Metabolic Disease·S E WaisbrenJ Warner-Rogers
Oct 6, 2000·Controlled Clinical Trials·A M ShermanJ K Ockene
May 3, 2001·Journal of Developmental and Behavioral Pediatrics : JDBP·L M MacknerL J Stark
Apr 10, 2003·European Journal of Pediatrics·Jolita BekhofPaul H Verkerk
Jun 16, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Carolyn E Ievers-LandisDouglas Kerr

❮ Previous
Next ❯

Citations

Feb 10, 2011·Journal of Inherited Metabolic Disease·Ulrike MützeWieland Kiess
Dec 18, 2013·Orphanet Journal of Rare Diseases·Tobias S HagedornRosalia Pasqual Saludes
Apr 8, 2010·Journal of Inherited Metabolic Disease·Anita MacDonaldPeter Burgard
Oct 25, 2011·Molecular Genetics and Metabolism·M DemirkolJ Walter
Sep 29, 2011·Molecular Genetics and Metabolism·A MacDonaldF Feillet
Apr 7, 2009·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S EvansA MacDonald
Aug 9, 2011·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A MacDonaldJ Wildgoose
Jul 8, 2011·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·H Gokmen-OzelA MacDonald
Feb 24, 2011·Acta Paediatrica·G CotugnoV Di Ciommo
Nov 20, 2015·Health·Stefan Timmermans, Sara Shostak
Aug 22, 2017·Nutrition & Metabolism·Ewa WitalisUNKNOWN Polish Society of Phenylketonuria
Jan 10, 2019·Orphanet Journal of Rare Diseases·Nataliya YuskivUNKNOWN Canadian Inherited Metabolic Diseases Research Network (CIMDRN)
Dec 5, 2012·Annals of Nutrition & Metabolism·A MaCdonaldF J van Spronsen
Oct 14, 2017·Orphanet Journal of Rare Diseases·A M J van WegbergF J van Spronsen
Mar 26, 2021·American Journal of Medical Genetics. Part a·Katia Irie TeruyaIda Vanessa Doederlein Schwartz
May 22, 2021·Nature Reviews. Disease Primers·Francjan J van SpronsenAnnet M Bosch
Aug 28, 2021·Nutrients·Rodolfo Ramos-ÁlvarezSusan E Waisbren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
S EvansAnita MacDonald
Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
Anita MacDonaldA Chakrapani
© 2022 Meta ULC. All rights reserved